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Titolo:
Mixed infection of Porphyromonas gingivalis and Bacteroides forsythus in amurine abscess model: involvement of gingipains in a synergistic effect
Autore:
Yoneda, M; Hirofuji, T; Anan, H; Matsumoto, A; Hamachi, T; Nakayama, K; Maeda, K;
Indirizzi:
Kyushu Univ, Fac Dent Sci, Div Oral Rehabil, Sect Periodontol,Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 tol,Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ, Fac Dent Sci, Div Oral Hlth Growth & Dev, Sect Oral Infect Dis & Immunol, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Dis & Immunol, Fukuoka 8128582, Japan
Titolo Testata:
JOURNAL OF PERIODONTAL RESEARCH
fascicolo: 4, volume: 36, anno: 2001,
pagine: 237 - 243
SICI:
0022-3484(200108)36:4<237:MIOPGA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEINASE ARG-GINGIPAIN; CYSTEINE PROTEINASE; PERIODONTAL-DISEASE; STRUCTURAL CHARACTERIZATION; FUSOBACTERIUM-NUCLEATUM; MOLECULAR-CLONING; RISK INDICATORS; LYS-GINGIPAIN; LESION MODEL; VIRULENCE;
Keywords:
Porphyromonas gingivalis; Bacteroides forsythus; mixed infection; gingipains;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Yoneda, M Kyushu Univ, Fac Dent Sci, Div Oral Rehabil, Sect Periodontol,Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan Kyushu Univ 3-1-1 MaidashiFukuoka Japan 8128582 8128582, Japan
Citazione:
M. Yoneda et al., "Mixed infection of Porphyromonas gingivalis and Bacteroides forsythus in amurine abscess model: involvement of gingipains in a synergistic effect", J PERIOD RE, 36(4), 2001, pp. 237-243

Abstract

Several microorganisms including Porphyromonas gingivalis and Bacteroides forsythus have been implicated to be etiologically important agents of periodontal disease. In this study, we determined the ability of combinations of periodontopathogenic microorganisms to cause tissue destruction in a marine abscess model. Although all bacterial combinations used in this study produced larger abscesses than did monoinfection or each bacterium. the combination of P. gingivalis and B. forsythus showed a synergistic effect on abscess formation. Since these two bacteria have been frequently found together in lesions of periodontitis, these results suggest the significance or their co-infection in the progression of periodontitis. P. gingivalis produces extracellular and cell-associated cysteine proteinases (gingipains) whichappear to be involved in its virulence. The rgpA rgpB double and kgp mutants induced significantly smaller abscesses than the wild type. Moreover, the rgpA rgpB kgp triple (gingipain-null) mutant hardly showed lesion formation at all with the experimental conditions used in this study, indicating that these genes encoding gingipains are important for virulence of P. gingivalis. Mixed infection of these P. gingivalis mutants with B. forsythus showed an additive effect on abscess formation, indicating that the gingipainsof P. gingivalis may play an important role in the pathological synergism between P. gingivalis and B. forsythus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 15:49:32