Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
VENOUS CONTRACTILE FUNCTION DURING AND AFTER HYPOTHERMIC EXPOSURE
Autore:
DAVIES MG; HOPKIN MA; HAGEN PO; BROCKBANK KGM;
Indirizzi:
DUKE UNIV,MED CTR,DEPT SURG,VASC BIOL & ATHEROSCLEROSIS RES LAB,BOX 3473 DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT SURG,VASC BIOL & ATHEROSCLEROSIS RES LAB DURHAM NC 27710
Titolo Testata:
Vascular surgery
fascicolo: 4, volume: 31, anno: 1997,
pagine: 441 - 448
SICI:
0042-2835(1997)31:4<441:VCFDAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENERGIC RESPONSES; SAPHENOUS-VEIN; RECEPTORS; REACTIVITY; BRADYKININ; GRAFTS; RABBIT; KININS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.G. Davies et al., "VENOUS CONTRACTILE FUNCTION DURING AND AFTER HYPOTHERMIC EXPOSURE", Vascular surgery, 31(4), 1997, pp. 441-448

Abstract

Hypothermia has been shown to have pathophysiological consequences onendothelial and smooth muscle cell functions. The impact of rewarmingon vessels is unknown, This study examines the contractile functions of two sets of rabbit external jugular veins, the first after equilibration at 37 degrees C and the second after cooling from 37 degrees C to 20 degrees C for one hour and following rewarming to 37 degrees C. The pharmacologic parameters: E-max (the maximal response expressed as a ratio of the contraction to 60 mM KCl) and the EC50 concentration, (which produces 50% of the maximal response) were calculated. Nonreceptor-mediated contractile responses (KCl) did not significantly change with cooling or on rewarming. The sensitivity to norepinephrine increased, whereas the E-max decreased significantly on cooling to 20 degreesC; both parameters returned to control levels on rewarming. Both the histamine sensitivity and E-max were decreased (P<0.05) with cooling. The E-max for histamine returned to normal on rewarming. In contrast to norepinephrine, the jugular vein sensitivity to histamine did not fully recover to untreated control values on rewarming. The sensitivity to bradykinin increased (P<0.05) with cooling and remained so on rewarming. The E-max for bradykinin decreased on cooling and dropped further upon rewarming (P<0.05). Thus, cooling produced a mixed pattern of alterations in response to contractile agonists, and rewarming did not result in a uniform restoration of these responses. These observationsmay have clinical implications for organ transplantation, for hypothermic surgery, and for individuals accidentally exposed to cold environmental conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 09:41:33