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Titolo:
Effects of depression on working memory in presymptomatic Huntington's disease
Autore:
Nehl, C; Ready, RE; Hamilton, J; Paulsen, JS;
Indirizzi:
Univ Iowa, Coll Med, Dept Psychol, Iowa City, IA 52242 USA Univ Iowa IowaCity IA USA 52242 d, Dept Psychol, Iowa City, IA 52242 USA Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 , Dept Psychiat, Iowa City, IA 52242 USA Univ Iowa, Dept Neurol, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 wa, Dept Neurol, Iowa City, IA 52242 USA Univ Calif San Diego, Sch Med, Dept Psychiat, San Diego, CA 92103 USA UnivCalif San Diego San Diego CA USA 92103 hiat, San Diego, CA 92103 USA
Titolo Testata:
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
fascicolo: 3, volume: 13, anno: 2001,
pagine: 342 - 346
SICI:
0895-0172(200122)13:3<342:EODOWM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE CARRIERS; MANIFESTATIONS; SYMPTOMS; ONSET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Paulsen, JS Univ Iowa, Coll Med, Dept Psychol, Psychiat Res 1-328 MEB, Iowa City, IA 52242 USA Univ Iowa Psychiat Res 1-328 MEB Iowa City IA USA 52242 42 USA
Citazione:
C. Nehl et al., "Effects of depression on working memory in presymptomatic Huntington's disease", J NEUROP CL, 13(3), 2001, pp. 342-346

Abstract

Cognitive decline may precede motor symptoms in Huntington's disease (HD). Depression is common in HD and has also been linked with cognitive impairment. The contribution of depression to cognition in individuals presymptomatic for HD (N = 15) was investigated. Tests from the Cambridge Automated Neuropsychological Assessment Battery measured visual and working memory. Depression was assessed with the Beck Depression Inventory and the Unified Huntington's Disease Rating Scale. Depressed mood and estimated time to disease onset, calculated by using DNA mutation length, both were significant predictors of working memory performance. Findings are consistent with and contribute to existing research with individuals presymptomatic for HD, identifying a potentially remediable contribution to cognitive decline (i.e., depressed mood).

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Documento generato il 10/08/20 alle ore 07:40:37