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Titolo:
Activated protein C resistance and acute ischaemic stroke: Relation to stroke causation and age
Autore:
Zunker, P; Hohenstein, C; Plendl, HJ; Zeller, JA; Caso, V; Georgiadis, D; Allardt, A; Deuschl, G;
Indirizzi:
Dept Surg, D-89312 Gunzburg, Germany Dept Surg Gunzburg Germany D-89312Dept Surg, D-89312 Gunzburg, Germany Kiel Univ Hosp, Dept Neurol, D-24105 Kiel, Germany Kiel Univ Hosp Kiel Germany D-24105 , Dept Neurol, D-24105 Kiel, Germany Kiel Univ Hosp, Inst Human Genet, D-24105 Kiel, Germany Kiel Univ Hosp Kiel Germany D-24105 t Human Genet, D-24105 Kiel, Germany Univ Hosp Perugia, Dept Neurol, I-06123 Perugia, Italy Univ Hosp Perugia Perugia Italy I-06123 t Neurol, I-06123 Perugia, Italy Univ Heidelberg Hosp, Dept Neurol, D-69120 Heidelberg, Germany Univ Heidelberg Hosp Heidelberg Germany D-69120 9120 Heidelberg, Germany
Titolo Testata:
JOURNAL OF NEUROLOGY
fascicolo: 8, volume: 248, anno: 2001,
pagine: 701 - 704
SICI:
0340-5354(200108)248:8<701:APCRAA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-V-LEIDEN; ISCHEMIC STROKE; VENOUS THROMBOSIS; RISK FACTOR; CEREBRAL-ISCHEMIA; YOUNG-ADULTS; MUTATION; PREVALENCE;
Keywords:
ischaemic stroke; thrombophilia; APC-resistance; TOAST criteria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Hohenstein, C Dept Surg, Ludwig Heilmeyer Str 1, D-89312 Gunzburg, GermanyDept Surg Ludwig Heilmeyer Str 1 Gunzburg Germany D-89312 y
Citazione:
P. Zunker et al., "Activated protein C resistance and acute ischaemic stroke: Relation to stroke causation and age", J NEUROL, 248(8), 2001, pp. 701-704

Abstract

Objectives Resistance to activated protein C (APC) is the most frequent cause of thrombophilia and a well known risk factor for deep and cerebral vein thrombosis. Its causative role in ischaemic stroke is still a matter of debate. We undertook this study to determine the prevalence of APC-resistance in a cohort of consecutive patients with acute ischaemic stroke, especially with respect to patients' age and the underlying stroke causation. Materials and methods 489 patients with proven ischaemic stroke were included inthis study. Subtypes of stroke were classified according to the TOAST criteria, i.e. large artery artherosclerosis (LAA), small vessel occlusion (SVO), cardioembolism (CE), stroke of other etiology (SOE), and stroke of undetermined etiology (SUE). APC-resistance was determined with a functional method with high sensitivity and specificity for the factor V Leiden mutation. The results were compared with the prevalence of APC-resistance in healthyvolunteers, all born in the same area. Results APC-resistance was found in24 of 489 patients (4.9 %) and in 6 of the 112 (5.4 %) control subjects. In the stroke patients, APC-resistance was distributed as follows: LAA 6.5 %(9/138), SVO 3.9 % (4/104), CE 6.7 % (7/104), SOE 3.6 % (1/28), SUE 2.6 % (3/115). Prevalence of APC-resistance was not significantly different between young stroke patients (6-45 years) and older patients (7.7 % [5/65] versus 4.5 % [19/424]). Conclusions Prevalence of APC-resistance is not increased in patients with ischaemic stroke. Additionally, no significant differences in the prevalence of APC-resistance are evident within the various stroke subtypes.

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Documento generato il 28/09/20 alle ore 10:22:31