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Titolo:
Atrial fibrillation: A risk factor for increased mortality - An AVID registry analysis
Autore:
Wyse, DG; Love, JC; Yao, Q; Carlson, MD; Cassidy, P; Greene, LH; Martins, JB; Ocampo, C; Raitt, MH; Schron, E; Stamato, NJ; Olarte, A;
Indirizzi:
Univ Calgary, Div Cardiol, Calgary, AB T2N 1N4, Canada Univ Calgary Calgary AB Canada T2N 1N4 rdiol, Calgary, AB T2N 1N4, Canada Maine Med Ctr, Dept Cardiol, Portland, ME 04102 USA Maine Med Ctr Portland ME USA 04102 Dept Cardiol, Portland, ME 04102 USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA Case Western Reserve Univ, Div Cardiol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Iowa Hosp & Clin, Div Cardiol, Iowa City, IA 52242 USA Univ Iowa Hosp& Clin Iowa City IA USA 52242 iol, Iowa City, IA 52242 USA Univ Rochester, Cardiol Unit, Rochester, NY USA Univ Rochester Rochester NY USA chester, Cardiol Unit, Rochester, NY USA Oregon Hlth Sci Univ, Div Cardiol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 ardiol, Portland, OR 97201 USA NHLBI, Clin Trials Res Grp, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MDUSA 20892 n Trials Res Grp, NIH, Bethesda, MD 20892 USA Wilson Reg Med Ctr, Cardiol Associates, Johnson City, NY USA Wilson Reg Med Ctr Johnson City NY USA Associates, Johnson City, NY USA
Titolo Testata:
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
fascicolo: 3, volume: 5, anno: 2001,
pagine: 267 - 273
SICI:
1383-875X(2001)5:3<267:AFARFF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-FAILURE; PROGNOSIS; STROKE;
Keywords:
atrial fibrillation; mortality; ventricular arrhythmias; antiarrhythmic drugs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Wyse, DG Univ Calgary, Div Cardiol, Room G009,3330 Hosp Dr NW, Calgary, ABT2N 1N4,Canada Univ Calgary Room G009,3330 Hosp Dr NW Calgary AB Canada T2N 1N4
Citazione:
D.G. Wyse et al., "Atrial fibrillation: A risk factor for increased mortality - An AVID registry analysis", J INTERV C, 5(3), 2001, pp. 267-273

Abstract

Emerging evidence suggests that atrial fibrillation is not a benign arrhythmia. It is associated with increased risk of death. The magnitude of association is controversial and potential causes remain unknown. Patients in the registry of the Antiarrhythmics Versus Implantable Defibrillators (AVID) Trial form the basis for this report. Baseline variables, in particular thepresence or absence of a history of atrial fibrillation/flutter, were examined in relation to survival. Multivariate Cox regression was used to adjust for differences in important baseline co-variables using 27 pre-selected variables. There were 3762 subjects who were followed for an average of 773+/- 420 days; 1459 (39 %) qualified with ventricular fibrillation and 2303(61 %) with ventricular tachycardia. A history of atrial fibrillation/flutter was present in 24.4 percent. There were many differences in baseline variables between those with and those without a history of atrial fibrillation/flutter. After adjustment for baseline differences, a history of atrial fibrillation/flutter remained a significant independent predictor of mortality, (relative risk=1.20; 95 % confidence intervals=1.03-1.40; p=0.020). Antiarrhythmic drug use, other than amiodarone or sotalol, was also a significant independent predictor of mortality (relative risk 1.34; 95 % confidence intervals 1.07-1.69, p=0.011. Atrial fibrillation/flutter is a significant independent risk factor for increased mortality in patients presenting with ventricular tachyarrhythmias. This risk may have been overestimated in previous studies that could not adjust for the proarrhythmic effects of antiarrhythmic drugs other than amiodarone or sotalol.

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Documento generato il 05/04/20 alle ore 06:55:16