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Titolo:
Reduction of extraction times in liquid-phase microextraction
Autore:
Halvorsen, TG; Pedersen-Bjergaard, S; Rasmussen, KE;
Indirizzi:
Univ Oslo, Sch Pharm, N-0316 Oslo, Norway Univ Oslo Oslo Norway N-0316Univ Oslo, Sch Pharm, N-0316 Oslo, Norway
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 2, volume: 760, anno: 2001,
pagine: 219 - 226
SICI:
1387-2273(20010905)760:2<219:ROETIL>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY GAS-CHROMATOGRAPHY; SAMPLE PREPARATION; HUMAN PLASMA; ELECTROPHORESIS; BENZODIAZEPINES; DERIVATIZATION; AMPHETAMINES; DRUGS; URINE; ASSAY;
Keywords:
extraction times; liquid-phase microextraction; methamphetamine; citalopram;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Halvorsen, TG Univ Oslo, Sch Pharm, POB 1068 Blindern, N-0316 Oslo, NorwayUniv Oslo POB 1068 Blindern Oslo Norway N-0316 Oslo, Norway
Citazione:
T.G. Halvorsen et al., "Reduction of extraction times in liquid-phase microextraction", J CHROMAT B, 760(2), 2001, pp. 219-226

Abstract

Recently, we introduced a simple and inexpensive disposable device for liquid-phase microextraction (LPME) based on porous polypropylene hollow fibres. In the present paper, extraction times were significantly reduced by an increase in the surface of the hollow fibres. The model compounds methamphetamine and citalopram, were extracted from 2.5 ml of urine, plasma, and whole blood after dilution with water and alkalisation with 125 mul of 2 M NaOH though a porous polypropylene hollow fibre impregnated with hexyl ether and into an aqueous acceptor phase consisting of 0.1 M HCl. Two commerciallyavailable hollow fibres, which differed in surface area, wall thickness and internal diameter, were compared. An increase in the contact area of the hollow fibre with the sample solution by a factor of approximately two resulted in reduction in equilibrium times by approximately the same factor. Thus, the model compounds were extracted to equilibrium within 15 min from both urine and plasma, and within 30 min from whole blood. For the first timeLPME was utilised to extract drugs from whole blood, and the extracts werecomparable with plasma both with regard to sample clean-up and extraction recoveries. Extraction recoveries for methamphetamine and citalopram. varied from 60 to 100% using the two fibres and the different matrices. (C) 2001Elsevier Science BV All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:24:04