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Titolo:
Temporary interruption of ceftazidime continuous infusion without reduction of activity: A computer-assisted simulation
Autore:
Castagnola, E; Da Ros, L;
Indirizzi:
G Gaslini Childrens Hosp, Infect Dis Unit, I-16147 Genoa, Italy G Gaslini Childrens Hosp Genoa Italy I-16147 Unit, I-16147 Genoa, Italy
Titolo Testata:
JOURNAL OF CHEMOTHERAPY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 395 - 401
SICI:
1120-009X(200108)13:4<395:TIOCCI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRITICALLY ILL PATIENTS; FEBRILE NEUTROPENIC PATIENTS; CANCER-PATIENTS; INTERMITTENT INFUSION; PHARMACOKINETICS; FEVER; MANAGEMENT; MONOTHERAPY; INFECTIONS; LEUKEMIA;
Keywords:
ceftazidime; neutropenia; continuous infusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Castagnola, E G Gaslini Childrens Hosp, Infect Dis Unit, Largo G Gaslini 5, I-16147 Genoa, Italy G Gaslini Childrens Hosp Largo G Gaslini 5 Genoa Italy I-16147
Citazione:
E. Castagnola e L. Da Ros, "Temporary interruption of ceftazidime continuous infusion without reduction of activity: A computer-assisted simulation", J CHEMOTHER, 13(4), 2001, pp. 395-401

Abstract

Continuous infusion (Cl) of ceftazidime has been demonstrated to add clinical advantages in the treatment of infection of neutropenic cancer patients, especially in the presence of Gram-negative bacteremia. However, this particular administration route is not always feasible in this particular clinical setting because of the patient's need of additional care or drug administration. The aim of this study was to evaluate, through a computer-assisted simulation, the modifications of drug concentration in presence of a single or repeated 2-hour interruptions of Cl ceftazidime in critically ill patients. Our analysis shows that a loading dose of 20 mg/kg, followed by a CI of 100/mg/kg/die, should be able to maintain efficacious plasma concentrations in all subjects, even when it is interrupted for a 2-hour period every 8 hours. Plasma concentrations after interruption should not fall below 8 mug/mLand for about 65-80% of time should reach levels equal to 5 times the MIC of the infecting pathogen. A 2-hour interruption of CI ceftazidime up to 3 times a day is likely to represent a safe and efficacious administration regimen that may enhance themanagement of the treatment of infectious complications in critically ill patients such as neutropenic cancer patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:48:32