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Titolo:
In vitro activity of tea tree oil against Candida albicans mycelial conversion and other pathogenic fungi
Autore:
DAuria, FD; Laino, L; Strippoli, V; Tecca, M; Salvatore, G; Battinelli, L; Mazzanti, G;
Indirizzi:
Univ Roma La Sapienza, Inst Microbiol, I-00185 Rome, Italy Univ Roma La Sapienza Rome Italy I-00185 Microbiol, I-00185 Rome, Italy
Titolo Testata:
JOURNAL OF CHEMOTHERAPY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 377 - 383
SICI:
1120-009X(200108)13:4<377:IVAOTT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELALEUCA-ALTERNIFOLIA; ANTIMICROBIAL ACTIVITY; IN-VITRO; MICONAZOLE;
Keywords:
Candida albicans; mycelial conversion; tea tree oil; cytocidal activity; dermatophytes; germ-tube inhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Mazzanti, G Univ Roma La Sapienza, Dept Pharmacol Nat Subst & Gen Physiol,Ple Aldo Moro 5, I-00185 Rome, Italy Univ Roma La Sapienza Ple Aldo Moro 5Rome Italy I-00185 taly
Citazione:
F.D. D'Auria et al., "In vitro activity of tea tree oil against Candida albicans mycelial conversion and other pathogenic fungi", J CHEMOTHER, 13(4), 2001, pp. 377-383

Abstract

The antifungal activity of Melaleuca alternifolia Maiden (Myrtaceae) essential oil against yeasts (Candida spp., Schizosaccharomyces pombe, Debaryomyces hansenii) and dermatophytes (Microsporum spp. and Tricophyton spp.) is reported. We focused on the ability of tea tree oil to inhibit Candida albicans conversion from the yeast to the pathogenic mycelial form. Moreover wecarried out broth microdilution test and contact tests to evaluate the killing time. M. alternifolia essential oil inhibited the conversion of C. albicans from yeast to the mycelial form at a concentration of 0.16% (v/v). The minimum inhibitory concentrations (MICs) ranged from 0.12% to 0.50% (v/v)for yeasts and 0.12% to 1% (v/v) for dermatophytes; the cytocidal activitywas generally expressed at the same concentration. These results, if considered along with the lipophilic nature of the oil which enables it to penetrate the skin, suggest it may be suitable for topical therapeutic use in the treatment of fungal mucosal and cutaneous infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 21:15:27