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Titolo:
Anti-inflammatory effects of 17 beta-estradiol pretreatment in men after coronary artery surgery
Autore:
Wei, MX; Kuukasjarvi, P; Kaukinen, S; Laurikka, J; Pehkonen, E; Laine, S; Moilanen, E; Metsanoja, R; Tarkka, M;
Indirizzi:
Tampere Univ Hosp, Div Cardiovasc Surg, Dept Anesthesia & Intens Care, FIN-33521 Tampere, Finland Tampere Univ Hosp Tampere Finland FIN-33521 , FIN-33521 Tampere, Finland Tampere Univ Hosp, Dept Clin Microbiol, Tampere, Finland Tampere Univ Hosp Tampere Finland Dept Clin Microbiol, Tampere, Finland Univ Tampere, Dept Pharmacol, Sch Publ Hlth, Biometry Unit, FIN-33101 Tampere, Finland Univ Tampere Tampere Finland FIN-33101 Unit, FIN-33101 Tampere, Finland
Titolo Testata:
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
fascicolo: 4, volume: 15, anno: 2001,
pagine: 455 - 459
SICI:
1053-0770(200108)15:4<455:AEO1BP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE REPLACEMENT THERAPY; TUMOR-NECROSIS-FACTOR; POSTMENOPAUSAL WOMEN; CONTRACTILE FUNCTION; MYOCARDIAL-ISCHEMIA; REPERFUSION INJURY; BETA-ESTRADIOL; VESSEL WALL; ESTROGEN; BLOOD;
Keywords:
17 beta-estradiol; coronary artery bypass graft surgery; leukocyte activation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Tarkka, M Tampere Univ Hosp, Div Cardiovasc Surg, Dept Anesthesia & IntensCare, POB2000, FIN-33521 Tampere, Finland Tampere Univ Hosp POB 2000 Tampere Finland FIN-33521 e, Finland
Citazione:
M.X. Wei et al., "Anti-inflammatory effects of 17 beta-estradiol pretreatment in men after coronary artery surgery", J CARDIOTHO, 15(4), 2001, pp. 455-459

Abstract

Objective: To investigate the anti-inflammatory and hemodynamic effects of17 beta -estradiol in men undergoing elective coronary artery bypass graftsurgery (CABG). Design: Prospective, randomized, controlled. Setting: Operating room and intensive care unit in a university hospital. Participants: Twenty-one men undergoing primary, elective CABG surgery. Intervention: 17 beta -estradiol, 2mg, was given orally twice in 14 hours before the operation. Measurements and Main Result. Leukocyte counts, plasma myeloperoxidase, tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, and IL-10 were measured perioperatively. Leukocyte counts were lower in the 17 beta -estradiol group than in controls at 6 hours (11.4 +/- 2.0 hours v 15.5 +/- 4.7 hours X 10(9)/L) and 20 hours (11.6 +/- 1.9 hours v 13.6 +/- 2.5 hours x 109/L) after reperfusion (p = 0.03). The release of myeloperoxidase was lower in the 17 beta -estradiol group than in controls (5 minutes; 634.4 +/- 213.1 mug/mL v 773.1 +/- 209.3 mug/mL; 4 hours, 305.0 +/- 108.0 mug/mL v 441.3 +/- 191.6 mug/mL; p = 0.02). Systemic vascular resistance index was lower just after cardiopulmonary bypass, and cardiac index was higher postoperatively in the 17 beta -estradiol group as compared with controls. Conclusion: Pretreatment with 17 beta -estradiol can limit leukocyte activation in men after CABG surgery. Copyright (C) 2001 by WB. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:36:20