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Titolo:
Impact of off-pump coronary artery surgery on myocardial performance and beta-adrenoceptor function
Autore:
Eldrup, N; Rasmussen, NH; Yndgaard, S; Bigler, D; Berthelsen, PG;
Indirizzi:
Univ Copenhagen, Gentofte Hosp, Dept Anesthesiol, DK-2900 Hellerup, Denmark Univ Copenhagen Hellerup Denmark DK-2900 siol, DK-2900 Hellerup, Denmark
Titolo Testata:
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
fascicolo: 4, volume: 15, anno: 2001,
pagine: 428 - 432
SICI:
1053-0770(200108)15:4<428:IOOCAS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
OCTOPUS TISSUE STABILIZER; CARDIAC-SURGERY; BEATING HEART; BYPASS; COLLATERALS; MORTALITY;
Keywords:
beating heart surgery; beta-adrenoceptors; beta-receptor function; cardiac output; hemodynamics; isoprenaline; isoproterenol; Octopus; off-pump coronary artery bypass surgery; revascularization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Berthelsen, PG Univ Copenhagen, Gentofte Hosp, Dept Anesthesiol, Niels Andersens Vej 65, DK-2900 Hellerup, Denmark Univ Copenhagen Niels Andersens Vej 65 Hellerup Denmark DK-2900
Citazione:
N. Eldrup et al., "Impact of off-pump coronary artery surgery on myocardial performance and beta-adrenoceptor function", J CARDIOTHO, 15(4), 2001, pp. 428-432

Abstract

Objective: To determine the hemodynamic changes during beating heart revascularization of the left anterior descending artery, the circumflex artery,and the right coronary artery as well as cardiovascular beta -adrenoceptorfunction before and after off-pump coronary artery bypass surgery. Design: Prospective study. Setting: University department of cardiothoracic anesthesia. Participants: Twenty patients scheduled for off-pump coronary artery bypass surgery using the Octopus 2 stabilizer system. Interventions: Isoproterenol, 4 mug, was administered intravenously after induction of anesthesia and again after surgery to monitor cardiac beta -receptor function. Measurements and Main Results: The hemodynamic responses to isoproterenol and cardiovascular variables were monitored before, during, and after immobilization of the target coronary artery with catheters in the radial and pulmonary arteries. During surgery on the left anterior descending artery (n = 23), stroke volume and cardiac index decreased 17 mL (21%) and 400 mL (17%). During revascularization of the circumflex artery (n = 9), stroke volume and cardiac index decreased 19 mL (28%) and 300 mL (17%). During surgery on the posterior aspect of the heart (n = 13), stroke volume and cardiac index decreased 22 mL (29%) and 400 mL (17%). All the cardiovascular variables had returned to baseline values 5 minutes after releasing the heart. The hemodynamic responses to isoproterenol were equal before and after surgery. Conclusion: This study provides evidence that the hemodynamic changes associated with off-pump surgery on the 3 major coronary arteries are similar and of short duration. No desensitization of cardiovascular beta -adrenoceptors was found. This finding is in contrast to the deterioration in beta -adrenoceptor function seen after surgery with cardiopulmonary bypass. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:21:38