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Titolo:
DNA binding-independent transcriptional activation by the androgen receptor through triggering of coactivators
Autore:
Slagsvold, T; Kraus, I; Fronsdal, K; Saatcioglu, F;
Indirizzi:
Univ Oslo, Ctr Biotechnol, N-0349 Oslo, Norway Univ Oslo Oslo Norway N-0349 v Oslo, Ctr Biotechnol, N-0349 Oslo, Norway Univ Oslo, Dept Biochem, N-0349 Oslo, Norway Univ Oslo Oslo Norway N-0349 niv Oslo, Dept Biochem, N-0349 Oslo, Norway Univ Oslo, Dept Biol, N-0349 Oslo, Norway Univ Oslo Oslo Norway N-0349Univ Oslo, Dept Biol, N-0349 Oslo, Norway Univ Oslo, Inst Clin Med, N-0349 Oslo, Norway Univ Oslo Oslo Norway N-0349 iv Oslo, Inst Clin Med, N-0349 Oslo, Norway
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 33, volume: 276, anno: 2001,
pagine: 31030 - 31036
SICI:
0021-9258(20010817)276:33<31030:DBTABT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID-HORMONE RECEPTOR; AMINO-TERMINAL DOMAIN; NUCLEAR RECEPTORS; ESTROGEN-RECEPTOR; LIGAND-BINDING; MOLECULAR MECHANISMS; RETINOIC ACID; AF2 DOMAINS; PROTEIN; FUNCTION-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Saatcioglu, F Univ Oslo, Ctr Biotechnol, Gaustadalleen 21, N-0349 Oslo, Norway Univ Oslo Gaustadalleen 21 Oslo Norway N-0349 Oslo, Norway
Citazione:
T. Slagsvold et al., "DNA binding-independent transcriptional activation by the androgen receptor through triggering of coactivators", J BIOL CHEM, 276(33), 2001, pp. 31030-31036

Abstract

Androgens have critical roles in the development and maintenance of the male reproductive system and are important for progression of prostate cancer. The effects of androgens are mediated by the androgen receptor (AR), which is a ligand-modulated transcription factor that belongs to the nuclear receptor superfamily. In the presence of androgens, AR binds to androgen response elements in the vicinity of androgen receptor target genes and activates transcription. In addition, liganded AR can interfere with the activity of other transcription factors, such as activator protein-1 and nuclear factor kappaB, for which DNA binding by AR is not necessary. In this study, wedescribe a novel ligand-dependent transactivation function for AR that is independent of its DNA binding ability. AR dramatically increased the intrinsic transcriptional activity of the nuclear receptor coactivators glucocorticoid receptor-interacting protein-1 (GRIP1), cAMP response element-binding protein-binding protein, and p300 that are tethered to DNA. This "triggering" phenomenon required both similar and distinctly different regions of AR compared with those needed for ligand-dependent transactivation from androgen-responsive elements. Furthermore, the domains of GRIP1 required for triggering by AR are different from those required when GRIP1 serves as a coactivator for AR at androgen-responsive promoters. These data suggest that triggering may constitute an important part of the mechanism by which AR regulates transcription.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 13:54:43