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Titolo:
Molecular pathways involved in response to ionizing radiation of ID-8 mouse ovarian cancer cells expressing exogenous full-length Brca1 or truncated Brca1 mutant
Autore:
Sylvain, V; LaFarge, S; Bignon, YJ;
Indirizzi:
Ctr Jean Perrin, Oncol Mol Lab, F-63011 Clermont Ferrand 1, France Ctr Jean Perrin Clermont Ferrand France 1 011 Clermont Ferrand 1, France
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 3, volume: 19, anno: 2001,
pagine: 599 - 607
SICI:
1019-6439(200109)19:3<599:MPIIRT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-DAMAGE RESPONSE; EARLY EMBRYONIC LETHALITY; MAMMARY EPITHELIAL-CELLS; TRANSCRIPTIONAL ACTIVATION; BREAST-CANCER; GENE-EXPRESSION; MEIOTIC CELLS; PHOSPHORYLATION; CYCLE; REPAIR;
Keywords:
Brca1; cellular response to ionizing radiation; mouse ovarian cancer cell line;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Bignon, YJ Ctr Jean Perrin, Oncol Mol Lab, 58 Rue Montalembert,BP 392, F-63011 Clermont Ferrand 1, France Ctr Jean Perrin 58 Rue Montalembert,BP 392 Clermont Ferrand France 1
Citazione:
V. Sylvain et al., "Molecular pathways involved in response to ionizing radiation of ID-8 mouse ovarian cancer cells expressing exogenous full-length Brca1 or truncated Brca1 mutant", INT J ONCOL, 19(3), 2001, pp. 599-607

Abstract

BRCA1 germline mutations have been linked to the development of hereditarybreast and ovarian cancers. Recent studies suggest that BRCA1 may functionin the regulation of basic cellular processes, including gene transcription, and sensing and/or repair of DNA damage. To further delineate the BRCA1 upstream and downstream steps involved in its role in the cellular responseto ionizing radiation, we compared the effects of expression of an exogenous full-length Brca1 with those of a truncated Brca1 mutant in the ID-8 mouse ovarian cancer cell line after irradiation. We found that expression of both full-length and truncated Brca1 increased resistance to ionizing radiation. Expression of truncated, but not full-length, Brca1 then allowed us to identify new potential downstream targets of mutated BRCA1 like MAPK/ERK pathway members and also key genes involved in mutated BRCA1 signaling pathway response to ionizing radiation such as p53 and p21(WAF1/CIP1). We therefore established an in vitro mouse model for studying, the molecular effects of human BRCA1 germline mutations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:12:58