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Titolo:
P53 and hMSH2 expression in basal cell carcinomas and malignant melanomas from photoexposed areas of head and neck region
Autore:
Staibano, S; Lo Muzio, L; Pannone, G; Somma, P; Farronato, G; Franco, R; Bambini, F; Serpico, R; De Rosa, G;
Indirizzi:
Univ Naples Federico II, Fac Med & Surg, Pathol Sect, Dept Biomorphol & Funct Sci, Naples, Italy Univ Naples Federico II Naples Italy morphol & Funct Sci, Naples, Italy Univ Ancona, Inst Dent Sci, Ancona, Italy Univ Ancona Ancona ItalyUniv Ancona, Inst Dent Sci, Ancona, Italy Univ Naples Federico II, Dept Dent Sci, Naples, Italy Univ Naples FedericoII Naples Italy o II, Dept Dent Sci, Naples, Italy Univ Bari, Dept Dent & Surg, Bari, Italy Univ Bari Bari ItalyUniv Bari, Dept Dent & Surg, Bari, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 3, volume: 19, anno: 2001,
pagine: 551 - 559
SICI:
1019-6439(200109)19:3<551:PAHEIB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPAIR GENE HMSH2; SKIN-CANCER; MICROSATELLITE INSTABILITY; DNA-DAMAGE; MOLECULAR ABNORMALITIES; ULTRAVIOLET-A; MURINE SKIN; MOUSE SKIN; MUTATIONS; UV;
Keywords:
p53; hMSH2; UV; skin cancers; basal cell carcinoma; melanoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Lo Muzio, L Via Carelli 28, I-71100 Foggia, Italy Via Carelli 28 Foggia Italy I-71100 8, I-71100 Foggia, Italy
Citazione:
S. Staibano et al., "P53 and hMSH2 expression in basal cell carcinomas and malignant melanomas from photoexposed areas of head and neck region", INT J ONCOL, 19(3), 2001, pp. 551-559

Abstract

Ultraviolet (UV) radiation plays a pivotal role in skin damage and photocarcinogenesis. The basic mechanism of phototoxicity lies in DNA damage, and involves mutation of tumor suppressor genes, oncogenes and genes directly involved in the control of the stability of genome, such as the mismatch repair (MR) genes. The goal of this study was to evaluate the role of p53 and hMSH2 in the UV-related carcinogenetic process. An immunohistochemical study for p53 and hMSH2 was performed in a series of 43 basal cell carcinomas (BCC) and 60 melanomas (MM) from photoexposed areas of head and neck region,comparing the findings with follow-up. A deregulated p53 expression characterized less differentiated, more aggressive BCC (BCC2) but not the well-differentiated ones (BCC1). The hMSH2 protein was present, though expressed at varying levels, in 18 out of 21 BCC1 cases and in 4 out of 22 BCC2. In the remaining 3 cases of BCC1 and 18 cases of BCC2, a complete absence of hMSH2 expression was found, correlating directly with the presence of recurrence and/or death of the disease in case of melanoma (p<0.05). Overall, the expression of hMSH2 correlated inversely with the p53 overexpression (p<0.01). In MM, p53 was found overexpressed in 81.6% of the cases, and this correlated positively with the level of infiltration and with the presence of relapses (p<0.01) or metastasis (p<0.01) and inversely with the disease-free interval (p<0.05). These results are in agreement with the reported association between p53 deregulation and a more aggressive cancer phenotype. The evaluation of the expression of p53 and hMSH2 could improve the management of patients with BCC and MM, and could have a role also in the evaluation ofthe early cutaneous photo-inducted damage, contributing to the identification of presymptomatic patients predisposed to the development of UV-relatednew skin tumors, who could become candidates for chemoprevention trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:38:47