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Titolo:
Neuropathological correlates to clinically defined dementia with Lewy bodies
Autore:
Londos, E; Passant, U; Gustafson, L; Brun, A;
Indirizzi:
Univ Lund Hosp, Dept Psychogeriatr, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 Psychogeriatr, SE-22185 Lund, Sweden Univ Lund Hosp, Dept Pathol, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 , Dept Pathol, SE-22185 Lund, Sweden
Titolo Testata:
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
fascicolo: 7, volume: 16, anno: 2001,
pagine: 667 - 679
SICI:
0885-6230(200107)16:7<667:NCTCDD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; BODY DISEASE; PARKINSONS-DISEASE; EXTRAPYRAMIDAL SIGNS; VASCULAR DEMENTIA; SENILE DEMENTIA; CRITERIA; DIAGNOSIS; VARIANT; IMMUNOCYTOCHEMISTRY;
Keywords:
Lewy body dementia; Alzheimer pathology; white matter disease; Alzheimer's disease; substantia nigra; vascular pathology; neuropathology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Londos, E Univ Lund Hosp, Dept Psychogeriatr, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 atr, SE-22185 Lund, Sweden
Citazione:
E. Londos et al., "Neuropathological correlates to clinically defined dementia with Lewy bodies", INT J GER P, 16(7), 2001, pp. 667-679

Abstract

Objectives To analyse the neuropathological changes behind clinically defined dementia with Lewy bodies (clinDLB) compared with clinically diagnosed Alzheimer's disease (clinAD). Methods The prevalence of neuropathological findings in 48 clinDLB and 45 clinAD cases was compared. Sixteen clinDLB and 10 clinAD cases were reassessed with alpha -synuclein staining for Lewy bodies (LB). Results Alzheimer pathology was found in 81% of the clinDLB and 93% of theclinAD cases. The clinDLB group had a higher prevalence of frontal white matter pathology, mostly of ischemic type, and a more severe degeneration ofthe substantia nigra compared with the clinAD group. In hematoxylin-eosin staining, LBs were identified in seven (15%) of the clinDLB and in four (9%) of the clinAD group. In a-synuclein staining, 38% of the clinDLB and 40% of the clinAD cases exhibited LBs. The cases without LBs, in the clinDLB group, had AD pathology in combination with frontal white matter disease. Vascular pathology of significant degree was prevalent in more than 40% of allthe cases with verified LBs regardless of clinical diagnosis. Conclusion Consecutive dementia cases, fulfilling the clinical consensus criteria for DLB, may exhibit combinations of neuropathological changes which in themselves can explain the clinical picture of DLB even when LBs are absent. Copyright (C) 2001 John Wiley & Sons, Ltd.

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Documento generato il 19/01/20 alle ore 14:37:22