Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Treatment with cathepsin L inhibitor potentiates T(h)2-type immune response in Leishmania major-infected BALB/c mice
Autore:
Zhang, T; Maekawa, Y; Sakai, T; Nakano, Y; Ishii, K; Hisaeda, H; Dainichi, T; Asao, T; Katunuma, N; Himeno, K;
Indirizzi:
Univ Tokushima, Sch Med, Dept Parasitol & Immunol, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 Immunol, Tokushima 7708503, Japan Talho Pharmaceut Co, Chem Lab, Hanno 357, Japan Talho Pharmaceut Co Hanno Japan 357 aceut Co, Chem Lab, Hanno 357, Japan Tokushima Bunri Univ, Inst Hlth Sci, Tokushima 7708514, Japan Tokushima Bunri Univ Tokushima Japan 7708514 i, Tokushima 7708514, Japan
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 8, volume: 13, anno: 2001,
pagine: 975 - 982
SICI:
0953-8178(200108)13:8<975:TWCLIP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MHC CLASS-II; INVARIANT CHAIN; EPOXYSUCCINYL PEPTIDES; DEGRADATION; TH2; PROTEINASES; PROTEASES; SELECTION; OVALBUMIN; GAMMA;
Keywords:
antigen processing; lysosomal proteases; protozoan parasites; T(h)1; T(h)2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Maekawa, Y Univ Tokushima, Sch Med, Dept Parasitol & Immunol, 3 Kuramoto Cho, Tokushima 7708503, Japan Univ Tokushima 3 Kuramoto Cho Tokushima Japan7708503 3, Japan
Citazione:
T. Zhang et al., "Treatment with cathepsin L inhibitor potentiates T(h)2-type immune response in Leishmania major-infected BALB/c mice", INT IMMUNOL, 13(8), 2001, pp. 975-982

Abstract

Prior to the activation of CD4(+) T cells, exogenous proteins must be digested by endo/lysosomal enzymes in antigen-presenting cells (APC) to produceantigenic peptides that are able to be presented on class II molecules of the MHC. Studies described here inspect the functional significance of cathepsin L inhibition for antigen processing and T(h)1/T(h)2 differentiation in experimental leishmaniasis. We first demonstrated using in vitro systems that cathepsin L is one of the candidate endo/lysosomal enzymes in processing of soluble Leishmania antigen (SLA) and that its specific inhibitor, CLIK148, modulated the processing of SLA. BALB/c mice are known to be susceptible to infection with Leishmania major Interestingly, treatment of BALB/c mice with CLIK148 exacerbated the infection by enhancing the development of SLA-specific T(h)2-type response such as production of IL-4 and generation of T(h)2-dependent specific IgE/IgG1 antibodies. Moreover, addition of CLIK148 in incubation of a SLA-specific CD4(+) T cell line with APC upregulatedthe production of IL-4. However, CLIK148 did not exert any direct influence on the function of T cells themselves. Taken together, these findings suggest that treatment of host mice with CLIK148 affects the processing of SLAin APC, resulting in the potentiation of Th-2-type immune responses and thus leading to exacerbation of the infection. Furthermore, endo/lysosomal cathepsin L was found to be functionally distinct from previously described cathepsins B and D.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:30:35