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Titolo:
Microchimerism and systemic sclerosis
Autore:
Scaletti, C; Vultaggio, A; Maggi, E; Romagnani, S; Piccinni, MP;
Indirizzi:
Univ Florence, Dept Internal Med, Sect Immunoallergol & Resp Dis, I-50134 Florence, Italy Univ Florence Florence Italy I-50134 & Resp Dis, I-50134 Florence, Italy
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 3, volume: 125, anno: 2001,
pagine: 196 - 202
SICI:
1018-2438(200107)125:3<196:MASS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERSUS-HOST DISEASE; HUMAN T-CELLS; TH2-TYPE CYTOKINES; CD30 EXPRESSION; ANTINUCLEAR ANTIBODIES; SUCCESSFUL PREGNANCY; ENDOTHELIAL-CELLS; SCLERODERMA SKIN; ACTIVATION; ORIGIN;
Keywords:
systemic sclerosis; microchimerism; pregnancy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Scaletti, C Univ Florence, Dept Internal Med, Sect Immunoallergol & Resp Dis, Viale Morgagni 85, I-50134 Florence, Italy Univ Florence Viale Morgagni85 Florence Italy I-50134 Italy
Citazione:
C. Scaletti et al., "Microchimerism and systemic sclerosis", INT A AL IM, 125(3), 2001, pp. 196-202

Abstract

Systemic sclerosis (SSc) is a connective tissue disease characterized by progressive fibrosis of the skin and internal organs. SSc is an immunologically mediated disease. A prominent immunological abnormality in SSc patientsis the presence of circulating autoantibodies against a variety of nuclearproteins. Furthermore, SSc is characterized by the presence of increased numbers of activated T cells, with the prevalence of CD4+ cells, present in the periphery of skin lesions as well as in other organs in the early stages of the disease. We have recently shown the existence of a predominant activation of IL-4-producing Th2-like T cells in patients with SSc, which may account for the major alterations which occur in this disease. SSc has clinical and serological similarities to chronic graft versus host disease (cGVHD), although there are some important differences. T cells, which orchestrate the tissue damage, are present in great amounts in the inflammatory infiltrates in SSc- and cGVHD-affected tissues. More importantly, T cells fromcGVHD tissues produce Th2-like cytokines, thus showing a pathogenetic similarity with SSc. SSc has been postulated as a type of cGVHD resulting from the transplacental transfer of cells between mother and fetus. Very recently, we have shown that in SSc, the microchimeric T cells react with the maternal MHC antigens and are able to produce Th2-type cytokines. Both featuresare characteristics of cGVHD, supporting the hypothesis that SSc is a disease similar to cGVHD. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:42:32