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Titolo:
DETECTION OF PNEUMOCYSTIS-CARINII DNA BY PCR AMPLIFICATION IN VARIOUSRAT ORGANS IN EXPERIMENTAL PNEUMOCYSTOSIS
Autore:
RABODONIRINA M; WILMOTTE R; DANNAOUI E; PERSAT F; BAYLE G; MOJON M;
Indirizzi:
UNIV LYON 1,DEPT PARASITOL & MYCOL,8 AVE ROCKEFELLER F-69373 LYON 08 FRANCE INST PASTEUR LYON,CNRS URA 1171 F-69365 LYON 07 FRANCE
Titolo Testata:
Journal of Medical Microbiology
fascicolo: 8, volume: 46, anno: 1997,
pagine: 665 - 668
SICI:
0022-2615(1997)46:8<665:DOPDBP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE-CHAIN-REACTION; IMMUNODEFICIENCY-VIRUS; PNEUMONIA; INFECTION; BLOOD; SEQUENCES; SPECIMENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
M. Rabodonirina et al., "DETECTION OF PNEUMOCYSTIS-CARINII DNA BY PCR AMPLIFICATION IN VARIOUSRAT ORGANS IN EXPERIMENTAL PNEUMOCYSTOSIS", Journal of Medical Microbiology, 46(8), 1997, pp. 665-668

Abstract

Pneumocystosis is usually a disease of the lungs, but the number of cases of extrapulmonary pneumocystosis has greatly increased during theAIDS epidemic, Much remains unknown about the frequency and mechanisms of dissemination, In the present study a systematic search for Pneumocystis carinii by PCR with primers specific for mitochondrial rRNA was performed in the lung, liver, spleen and kidney of 12 immunosuppressed rats and two immunocompetent rats, The amplified products were analysed by Southern hybridisation with a digoxigenin-11-dUTP labeled probe, P. carinii DNA was found in lungs in all 14 rats and in at least one organ other than lung in 11 immunosuppressed rats and the two control rats, We suggest that extrapulmonary dissemination may not be an exceptional phenomenon in the course of pneumocystosis, but rather part of the natural evolution of the disease.

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Documento generato il 02/12/20 alle ore 14:32:47