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Titolo:
Non-invasive markers of bone turnover and plasma cytokines differ in osteoporotic patients with multiple myeloma and monoclonal gammopathies of undetermined significance
Autore:
Diamond, T; Levy, S; Smith, A; Day, P; Manoharan, A;
Indirizzi:
Univ New S Wales, St George Hosp, Dept Endocrinol, Sydney, NSW 2217, Australia Univ New S Wales Sydney NSW Australia 2217 l, Sydney, NSW 2217, Australia Univ New S Wales, St George Hosp, Dept Biochem, Sydney, NSW 2217, Australia Univ New S Wales Sydney NSW Australia 2217 m, Sydney, NSW 2217, Australia Univ New S Wales, St George Hosp, Dept Haematol, Sydney, NSW 2217, Australia Univ New S Wales Sydney NSW Australia 2217 l, Sydney, NSW 2217, Australia
Titolo Testata:
INTERNAL MEDICINE JOURNAL
fascicolo: 5, volume: 31, anno: 2001,
pagine: 272 - 278
SICI:
1444-0903(200107)31:5<272:NMOBTA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE-ACTIVITY; SERUM; RESORPTION; COLLAGEN; TELOPEPTIDE; BIOLOGY;
Keywords:
bone markers; cytokines; myeloma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Diamond, T Univ New S Wales, St George Hosp, Dept Endocrinol, Prichard Wing,Gray St, Sydney, NSW 2217, Australia Univ New S Wales Prichard Wing,Gray St Sydney NSW Australia 2217
Citazione:
T. Diamond et al., "Non-invasive markers of bone turnover and plasma cytokines differ in osteoporotic patients with multiple myeloma and monoclonal gammopathies of undetermined significance", INTERN M J, 31(5), 2001, pp. 272-278

Abstract

Aims: To determine whether various markers of bone turnover and/or plasma cytokines differ in patients with multiple myeloma (MM) compared with patients with monoclonal gammopathies of undetermined significance (MGUS). Methods: We studied 22 MM patients and 18 MGUS patients presenting over an18-month period and compared their data with those from 20 age- and sex-matched patients presenting with primary osteoporosis. According to the Salmon and Durie classification, there were eight patients with stage I, nine with stage II and five with stage III disease. All patients had densitometricevidence of osteoporosis and were classified according to bone marrow evidence of plasma cell dyscrasia. Measured variables included markers of bone formation and bone resorption, and plasma cytokines. Results: Patients with MM and MGUS did not differ with respect to their mean age, male : female sex ratio, height, weight, serum calcium, 25-hydroxyvitamin D and parathyroid hormone concentrations. Patients with MM had significantly lower concentrations of haemoglobin (109 vs 135 g/L) and serum transforming growth factor (TGF)-beta (261 vs 348 pg/mL) than patients with MGUS, and higher concentrations of serum paraproteins (31.1 vs 7.4 g/L), beta2-microglobulin (3.5 vs 2.2 g/L), % plasma cell numbers (35.3 vs 2.1%) and urinary deoxypyridinolinc excretion rates (u-DPYD; 7.7 vs 5.9 nmol/mmol creatinine; P < 0.05 for all comparisons). In multivariate analysis, the serumparaprotein (<beta> coefficient = -0.067; 95% confidence intervals (CI), -0.019 to -0.005; P = 0.0012), u-DPYD excretion rates (beta coefficient = -0.012; 95% CI, -0.113 to -0.02; P = 0.0058) and serum TGF-beta concentrations (beta coefficient = -0.002; 95% CI, -0.0002 to -0.02; P = 0.02) were the most important variables differentiating between MM and MGUS, after excluding lytic bone lesions, % plasma cell numbers and haemoglobin concentrations. Conclusions: The well-established criteria for diagnosing MM include the presence of lytic bone lesions, plasmacytosis, haemoglobin and paraprotein concentrations. The u-DPYD excretion rate, a sensitive non-invasive marker of bone resorption, may help in differentiating between MM and MGUS, as wellas serving as a marker of underlying bone disease activity in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:30:22