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Titolo:
Identification and characterization of a homologue of the pro-inflammatorycytokine Macrophage Migration Inhibitory Factor in the tick, Amblyomma americanum
Autore:
Jaworski, DC; Jasinskas, A; Metz, CN; Bucala, R; Barbour, AG;
Indirizzi:
Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 l & Mol Genet, Irvine, CA 92697 USA Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 ine, Dept Med, Irvine, CA 92717 USA Picower Inst Med Res, Manhasset, NY USA Picower Inst Med Res Manhasset NYUSA er Inst Med Res, Manhasset, NY USA
Titolo Testata:
INSECT MOLECULAR BIOLOGY
fascicolo: 4, volume: 10, anno: 2001,
pagine: 323 - 331
SICI:
0962-1075(200108)10:4<323:IACOAH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOST IMMUNITY; FACTOR MIF; PROSTAGLANDINS; PURIFICATION; TAUTOMERASE; HORMONE; SALIVA;
Keywords:
Amblyomma tick; macrophage inhibiting factor; cytokine; salivary gland; vector;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Jaworski, DC Univ Calif Irvine, Dept Microbiol & Mol Genet, B240 Med Sci 1, Irvine, CA 92697 USA Univ Calif Irvine B240 Med Sci 1 Irvine CA USA 926972697 USA
Citazione:
D.C. Jaworski et al., "Identification and characterization of a homologue of the pro-inflammatorycytokine Macrophage Migration Inhibitory Factor in the tick, Amblyomma americanum", INSEC MOL B, 10(4), 2001, pp. 323-331

Abstract

Studying tick feeding and digestion, we discovered in a cDNA library from partially fed Amblyomma americanum ticks the first known arthropod homologue of a human cytokine, the pro-inflammatory Macrophage Migration InhibitoryFactor (MIF). The tick origin of the MIF cDNA clone was confirmed by sequencing a genomic fragment that contained the full-length tick MIF gene with two introns. Antiserum to a tick MIF-specific peptide as well as antiserum to complete tick MIF revealed the expression of tick MIF in the salivary gland and midgut tissues of A. americanum, ticks. In an in vitro functional assay, recombinant tick MIF inhibited the migration of human macrophages to the same extent that recombinant human MIF did.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 03:38:21