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Titolo:
Endothelial nitric oxide synthase gene polymorphism in women with idiopathic recurrent miscarriage
Autore:
Tempfer, C; Unfried, G; Zeillinger, R; Hefler, L; Nagele, F; Huber, JC;
Indirizzi:
Univ Vienna, Sch Med, Dept Gynecol & Obstet, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 necol & Obstet, A-1090 Vienna, Austria Univ Vienna, Sch Med, Dept Gynaecol Endocrinol & Reprod Med, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 l & Reprod Med, A-1090 Vienna, Austria
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 8, volume: 16, anno: 2001,
pagine: 1644 - 1647
SICI:
0268-1161(200108)16:8<1644:ENOSGP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREGNANCY LOSS; ABORTION; HYPERTENSION; INHIBITION; REGION; CELLS; MOUSE; ENOS; MICE; TERM;
Keywords:
endothelial nitric oxide synthase; idiopathic recurrent miscarriage; nitric oxide; polymorphism; risk factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Nagele, F Univ Vienna, Sch Med, Dept Gynecol & Obstet, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090 tria
Citazione:
C. Tempfer et al., "Endothelial nitric oxide synthase gene polymorphism in women with idiopathic recurrent miscarriage", HUM REPR, 16(8), 2001, pp. 1644-1647

Abstract

BACKGROUND: Lack of endothelium-derived nitric oxide is associated with vasospasm and vascular infarction. We investigated the relationship between idiopathic recurrent miscarriage and a polymorphism of the gene encoding endothelial nitric oxide synthase (NOS3). METHOD: In a prospective case-control study, 105 women with idiopathic recurrent miscarriage and 91 healthy controls were investigated. We used the polymerase chain reaction to identify the different alleles of a 27 base pair tandem repeat polymorphism in intron 4 of the NOS3 gene. RESULTS: The wild type B allele was identified on 329out of 392 chromosomes (frequency 0.84). The polymorphic A allele was present on 63 chromosomes (frequency 0.16). The genotype frequencies were as follows: 68% (B/B), 31% (A/B) and .5% (A/A). The distribution of genotype frequencies was significantly different between the study and control groups for allele A/B heterozygotes (NOS3(A/B)) (36.7 versus 23.8%, P = 0.03, OR 1.6, 95% CI 1.1-3.8). Only one individual was homozygous for the A allele (NOS3(A/A)). She was in the study group. Between women with primary and secondary recurrent miscarriages, no statistically significant difference betweenthe distribution of NOS3(A/B) genotypes (28 versus 34%) was observed. CONCLUSIONS: These data support a role for the NOS3 gene as a genetic determinant of the risk of idiopathic recurrent miscarriage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:26:40