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Titolo:
Transforming growth factor beta 1 urokinase-type plasminogen activator andplasminogen activator inhibitor-1 mRNA expression in head and neck squamous carcinoma and normal adjacent mucosa
Autore:
Pasini, FS; Brentani, MM; Kowalski, LP; Federico, MHH;
Indirizzi:
Univ Sao Paulo, Dept Radio Disciplina Oncol, Sao Paulo, SP, Brazil Univ Sao Paulo Sao Paulo SP Brazil sciplina Oncol, Sao Paulo, SP, Brazil FMUSP, Hosp Clin, LIM 24, Sao Paulo, Brazil FMUSP Sao Paulo BrazilFMUSP, Hosp Clin, LIM 24, Sao Paulo, Brazil Hosp Canc AC Camargo, Dept Cirurgia Cabeca & Pesco & Otorrinolaringol, SaoCarlos, Brazil Hosp Canc AC Camargo Sao Carlos Brazil rrinolaringol, SaoCarlos, Brazil
Titolo Testata:
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
fascicolo: 9, volume: 23, anno: 2001,
pagine: 725 - 732
SICI:
1043-3074(200109)23:9<725:TGFB1U>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER CELL-LINES; IN-VITRO; TGF-BETA; ENDOTHELIAL-CELLS; EPITHELIAL-CELLS; ORAL CAVITY; PROTEIN; SYSTEM; SKIN; RNA;
Keywords:
head and neck squamous carcinoma; transforming growth factor beta 1; urokinase plasminogen activator and plasminogen activator inhibitor PAl-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Federico, MHH Univ Sao Paulo, Dept Radio Disciplina Oncol, Av Dr Arnaldo 455-4 Andar, Sao Paulo, SP, Brazil Univ Sao Paulo Av Dr Arnaldo 455-4 Andar Sao Paulo SP Brazil
Citazione:
F.S. Pasini et al., "Transforming growth factor beta 1 urokinase-type plasminogen activator andplasminogen activator inhibitor-1 mRNA expression in head and neck squamous carcinoma and normal adjacent mucosa", HEAD NECK, 23(9), 2001, pp. 725-732

Abstract

Background, A balance between urokinase-type plasminogen activator (uPA) and its main inhibitor type-1 (PAI-1) appears to be important for cancer invasive behavior, Since uPA/PAI-1 system seems to be regulated by transforming growth factor beta1 (TGF beta1) in different cell types, our aim was to investigate the relationship between the expression of the three genes and lymph node status in head and neck squamous cell carcinomas (HNSCC) at specific sites. Materials and Methods. uPA, PAI-1, and TGF beta1 mRNAs were determined by Northern analysis in tumor, and paired normal mucosa samples were obtained from 91 operable HNSCC patients. Results. In oral cavity, excluding tongue, TGF beta1, PAI-1, and uPA mRNAsvalues were consistently lower in the normal tissues than in tumors. In larynx tumors, TGF beta1 expression was increased, but no statistically significant differences were found for uPA or PAI-1 mRNAs as compared with normal tissues. Tongue tumors overexpressed only uPA mRNA, and uPA levels showedsignificant parallel variations with TGF beta1 and PAI-1 mRNAs mainly in pN+ tumors. In oral cavity tumors, an inverse correlation between TGF beta1 and uPA was observed in pN0 subgroup, elevated uPA mRNA was counterbalancedby high PAI-1 mRNA TGF beta1, and PAI-1 were not coordinately expressed, Correlations between the three markers were not found in larynx. Hypopharynxtumors, all staged as pN+, expressed the lowest TGF beta1 mRNA mean values. Conclusions. Combined information about TGF beta1, uPA, and PAI-1 mRNAs may add some clues to the understanding of the pathophysiological role of uPAsystem in head and neck squamous cell carcinoma. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:38:27