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Titolo:
Advanced hypopharyngeal carcinoma treatment results according to treatmentmodalities
Autore:
Kim, S; Wu, HG; Heo, DS; Kim, KH; Sung, MW; Park, CI;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Therapeut Radiol, Chongno Gu, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 o Gu, Seoul 110744, South Korea Seoul Natl Univ, Med Res Ctr, Inst Radiat Med, Seoul, South Korea Seoul Natl Univ Seoul South Korea , Inst Radiat Med, Seoul, South Korea Seoul Natl Univ Hosp, Clin Res Inst, Seoul 110744, South Korea Seoul Natl Univ Hosp Seoul South Korea 110744 Seoul 110744, South Korea Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea SeoulNatl Univ Seoul South Korea 151 ternal Med, Seoul 151, South Korea Seoul Natl Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 151, South Korea Seoul Natl Univ Seoul South Korea 151 Neck Surg, Seoul 151, South Korea
Titolo Testata:
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
fascicolo: 9, volume: 23, anno: 2001,
pagine: 713 - 717
SICI:
1043-3074(200109)23:9<713:AHCTRA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; PYRIFORM SINUS; NECK-CANCER; ADVANCED HEAD; RADIOTHERAPY; CHEMOTHERAPY; SURGERY; PRESERVATION; IRRADIATION; THERAPY;
Keywords:
hypopharyngeal carcinoma; surgery; radiation; therapy; neoadjuvant chemotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, HG Seoul Natl Univ, Coll Med, Dept Therapeut Radiol, Chongno Gu, 28 Yongon Dong, Seoul 110744, South Korea Seoul Natl Univ 28 Yongon Dong Seoul South Korea 110744 outh Korea
Citazione:
S. Kim et al., "Advanced hypopharyngeal carcinoma treatment results according to treatmentmodalities", HEAD NECK, 23(9), 2001, pp. 713-717

Abstract

Background. The purpose of this retrospective study is to compare the treatment results of locally advanced hypopharyngeal carcinoma according to treatment modalities. Methods, Seventy-three patients with locally advanced hypopharyngeal carcinoma treated at the Department of Therapeutic Radiology, Seoul National University Hospital, between August 1979 and July 1997 were retrospectively analyzed. Twenty-three patients were treated with radiotherapy (RT) alone, 18patients were treated with surgery and postoperative RT, and 32 patients were treated with neoadjuvant chemotherapy (CTx) and RT. Median follow-up period was 28 months. Results. The overall 5-year survival rates were 15.7% for the FIT alone group, 46.8% for surgery and postoperative FIT group, and 43.0% for neoadjuvant CTx and RT group, The 5-year disease-free survival rates were 13.9%, 47.4%, and 30.7%, respectively. Surgery and postoperative FIT or neoadjuvant CTx and FIT showed superiority over RT alone in terms of both overall survival and disease-free survival rates. No significant differences were found in overall and disease-free survival rates between the surgery and postoperative FIT group and neoadjuvant CTx and RT group (p = .15, p = .13). In the neoadjuvant CTx and FIT group, 12 patients (38%) retained their larynx morethan 5 years,Conclusion. Neoadjuvant CTx and RT is an effective strategy to achieve organ preservation without compromising the survival of patients with locally advanced hypopharyngeal carcinoma. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:25:06