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Titolo:
Cross talk of the interferon-alpha/beta signalling complex with gp130 for effective interleukin-6 signalling
Autore:
Mitani, Y; Takaoka, A; Kim, SH; Kato, Y; Yokochi, T; Tanaka, N; Taniguchi, T;
Indirizzi:
Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Immunol, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Fac Med, Bunkyo Ku, Tokyo 1130033, Japan
Titolo Testata:
GENES TO CELLS
fascicolo: 7, volume: 6, anno: 2001,
pagine: 631 - 640
SICI:
1356-9597(200107)6:7<631:CTOTIS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOKINE RECEPTORS; CAVEOLAE MEMBRANE; TRANSCRIPTIONAL ACTIVATION; JUNB PROMOTER; GROWTH-FACTOR; IFN-BETA; T-CELL; STAT3; TRANSDUCTION; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Taniguchi, T Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan Univ Tokyo Hongo 7-3-1 Tokyo Japan 1130033 yo 1130033, Japan
Citazione:
Y. Mitani et al., "Cross talk of the interferon-alpha/beta signalling complex with gp130 for effective interleukin-6 signalling", GENES CELLS, 6(7), 2001, pp. 631-640

Abstract

Background: Signalling cross talk provides a molecular basis for modulating a given signalling pathway by another, and it is often critical for regulating cellular responses elicited by cytokines. Previously, we reported on the critical role of the IFN-alpha/beta signalling complex, generated by spontaneously produced IFN-alpha/beta, in efficient IFN-gamma signalling. Results: In the present study, we have demonstrated that the IFN-alpha/beta signalling complex also contributes to efficient IL-6 signalling. In fact, IL-6-induced activation of the Stat1 and Stat3 transcription factors is markedly diminished in the absence of the IFN-alpha/beta signalling complex. The induction of several target genes for these factors is also diminished, both in vitro and in vivo. We provide evidence that the cytoplasmic tyrosine residues of IFNAR-1, which remains phosphorylated by a weak IFN-alpha/beta stimulation, provide docking sites for Stat1 and Stat3 to form homo- orheterodimers following IL-6 stimulation. Furthermore, a chemical cross-linking experiment revealed that IFNAR-1 and gp130, a common signal transducerfor the IL-6 family of cytokines, exist in close proximity. Conclusions: The constitutive weak IFN-alpha/beta signal provides a foundation for strong cellular responses to IL-6, IFN-gamma, and possibly other cytokines. Our results also suggest the assembly of cytokine receptor subunits, which may represent a 'receptosome'-Iike structure, allowing the uniquesignalling cross talks to occur.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 06:43:20