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Titolo:
Age-dependent presence of antibodies in rat dams, capable of conferring protection against group B Streptococcus infection in neonates
Autore:
Moore, JC; Muckett, PJ; Hughes, MJG;
Indirizzi:
Micosci Ltd, Wokingham RG41 5TU, England Micosci Ltd Wokingham England RG41 5TU Ltd, Wokingham RG41 5TU, England Univ Reading, Sch Anim & Microbial Sci, Bioresource Unit, Reading, Berks, England Univ Reading Reading Berks England esource Unit, Reading, Berks, England
Titolo Testata:
FEMS MICROBIOLOGY LETTERS
fascicolo: 1, volume: 202, anno: 2001,
pagine: 125 - 127
SICI:
0378-1097(20010807)202:1<125:APOAIR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSCEPTIBILITY; CONJUGATE;
Keywords:
group B Streptococcus; neonatal protection; maternal antibody;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Hughes, MJG Micosci Ltd, 545 Eskdale Rd,Winnersh Triangle, Wokingham RG41 5TU, England Micosci Ltd 545 Eskdale Rd,Winnersh Triangle Wokingham England RG41 5TU
Citazione:
J.C. Moore et al., "Age-dependent presence of antibodies in rat dams, capable of conferring protection against group B Streptococcus infection in neonates", FEMS MICROB, 202(1), 2001, pp. 125-127

Abstract

A rat model was used to investigate maternal age-dependent resistance on group B Streptococcus (GBS)-induced mortality of the offspring. Offspring from young (first time) or older (repeat litters) dams were challenged with GBS. There was an approximate log difference in the dose of GBS required to cause identical levels of mortality in the two groups. The sera of the damsfrom both groups were analysed by whole-cell ELISA, and it was demonstrated that sera from the older dams possessed circulating IgG cross-reactive toGBS. Since IgG is transplacentally transferred, we conclude that this is the method of observed protection. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V.. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:43:18