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Titolo:
Paradoxical effects of chronic corticosterone on forced swim behaviours inaged male and female rats
Autore:
Brotto, LA; Gorzalka, BB; Barr, AM;
Indirizzi:
Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada Univ British Columbia Vancouver BC Canada V6T 1Z4 ver, BC V6T 1Z4, Canada
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 424, anno: 2001,
pagine: 203 - 209
SICI:
0014-2999(20010727)424:3<203:PEOCCO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-MEDIATED BEHAVIORS; ANIMAL-MODEL; SEX-DIFFERENCES; ANTIDEPRESSANT DRUGS; MEMORY PERFORMANCE; INDUCED IMMOBILITY; CORTISOL-LEVELS; DEPRESSION; STRESS; GLUCOCORTICOIDS;
Keywords:
corticosterone; forced swim test; sex difference; depression; hypothalamic-pituitary-adrenal axis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Gorzalka, BB Univ British Columbia, Dept Psychol, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada Univ British Columbia 2136 West Mall Vancouver BC Canada V6T 1Z4
Citazione:
L.A. Brotto et al., "Paradoxical effects of chronic corticosterone on forced swim behaviours inaged male and female rats", EUR J PHARM, 424(3), 2001, pp. 203-209

Abstract

The effects of chronically administered corticosterone on forced swim testand open field test behaviours were explored in aged male and female rats. Though corticosterone has typically been associated with depressive behaviours, recent data have suggested a putative antidepressive effect of corticosterone. The current study used the forced swim test as a model of antidepressant efficacy in order to explore this. Aged male and female rats received either corticosterone (20 mg/kg) or the vehicle for 10 days before testing in the forced swim test, then for an additional 3 days before testing inthe open field test. On day 11, each animal was individually tested on theduration of swimming, immobile, and struggling behaviours, and on day 14, for the display of rearing and line crossing behaviours. Results revealed that corticosterone significantly increased swimming and decreased immobility behaviour in females, but failed to do so in males. Additionally, there was a main effect of corticosterone on straggling behaviour such that it decreased it in males. There were no effects of corticosterone or sex on open field test behaviours, suggesting that the present findings are not accounted for by a general effect of corticosterone on motor behaviour. Overall, the data suggest that chronically administered corticosterone possesses effects that are sex-specific, and that it may exert mildly antidepressive effects in females, but the opposite effects in males. These data are consistent with emerging evidence that corticosterone may play a paradoxical antidepressive effect. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 02/04/20 alle ore 08:55:15