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Titolo:
Role of adenosine and P2 receptors in the penile tumescence in anesthetized dogs
Autore:
Noto, T; Inoue, H; Mochida, H; Kikkawa, K;
Indirizzi:
Tanabe Seiyaku Co Ltd, Discovery Lab, Toda, Saitama 3358505, Japan Tanabe Seiyaku Co Ltd Toda Saitama Japan 3358505 , Saitama 3358505, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 425, anno: 2001,
pagine: 51 - 55
SICI:
0014-2999(20010803)425:1<51:ROAAPR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORPUS CAVERNOSUM; NITRIC-OXIDE; ERECTION; RELAXATION; POTENT; DESENSITIZATION; PHARMACOLOGY; STIMULATION; MECHANISMS; ANTAGONIST;
Keywords:
ATP; pelvic nerve; T-1032;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Noto, T Tanabe Seiyaku Co Ltd, Discovery Lab, 2-2-50 Kawagishi, Toda, Saitama 3358505, Japan Tanabe Seiyaku Co Ltd 2-2-50 Kawagishi Toda Saitama Japan 3358505
Citazione:
T. Noto et al., "Role of adenosine and P2 receptors in the penile tumescence in anesthetized dogs", EUR J PHARM, 425(1), 2001, pp. 51-55

Abstract

We studied the role of adenosine and P2 receptors in the pelvic nerve stimulation-induced penile tumescence in anesthetized dogs. A local intracavernous injection of adenosine induced the tumescence, which was abolished by intracavernous 8-(p-sulfophenyl)theophylline (8-SPT), an unspecific adenosine receptor antagonist, and by 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-yl amino]ethyl)phenol (ZM241385), an adenosine A(2A) receptor antagonist. ATP also induced the tumescence, which was diminished by 8-SPT, but not by reactive blue-2, a P2 receptor antagonist. Neither intracavernous beta, gamma -meATP nor ADP(beta)S, P2X and P2Y receptor agonists, induced tumescence. N-G-nitro-L-arginine (L-NAME), a nitric oxide synthase inhibitor, and T-1032, a phosphodiesterase type V inhibitor, had no effectson the tumescence induced by adenosine. S-SPT and reactive blue-2 had no effects on the tumescence induced by pelvic nerve stimulation. These resultsshow that although exogenous adenosine and ATP induce tumescence, neither the adenosine nor the P2 receptor is involved in the tumescence induced by pelvic nerve stimulation in anesthetized dogs. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:02:49