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Titolo:
Discharge threshold is enhanced for several seconds after a single interictal spike in a model of focal epileptogenesis
Autore:
de Curtis, M; Librizzi, L; Biella, G;
Indirizzi:
Ist Nazl Neurol, Dept Expt Neurophysiol, Milan, Italy Ist Nazl Neurol Milan Italy eurol, Dept Expt Neurophysiol, Milan, Italy
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 174 - 178
SICI:
0953-816X(200107)14:1<174:DTIEFS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG BRAIN; FIELD BURST ACTIVITY; RAT IN-VIVO; PIRIFORM CORTEX; EPILEPTIFORM ACTIVITY; TEMPORAL-LOBE; PATTERNS; SLICES; VITRO; HIPPOCAMPUS;
Keywords:
brain stimulation; epilepsy; guinea pig; in vitro; interictal spikes; isolated brain preparation; piriform cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: de Curtis, M Ist Nazl Neurol, Dept Expt Neurophysiol, Via Celoria 11, Milan, Italy Ist Nazl Neurol Via Celoria 11 Milan Italy 11, Milan, Italy
Citazione:
M. de Curtis et al., "Discharge threshold is enhanced for several seconds after a single interictal spike in a model of focal epileptogenesis", EUR J NEURO, 14(1), 2001, pp. 174-178

Abstract

Interictal spikes (ISs) are typically observed between seizures in focal epilepsies. Whether ISs are causally involved or represent protective elements in the transition toward an ictal discharge is an open question. Previous studies suggested that inhibition or disfacilitation occurs during the period elapsing between two ISs induced by local application of either bicuculline or penicillin in the piriform cortex of the in vitro isolated guinea pig brain preparation. We further investigated this issue by studying responses to afferent stimulation during the interspike period (6.3 +/- 2.5 s; mean +/- SD). Properly set stimulation intensity of the lateral olfactory tract resets ISs exclusively (and not before) 4-10 s (5.6 +/- 2.0 s; mean +/-SD) after a preceding spontaneous spike. This finding demonstrates the existence of a period of enhanced threshold to stimulus-evoked activation thatcoincides with the interspike interval in the absence of stimulation. Current source density analysis of depth laminar profiles demonstrated that both stimulus-evoked and spontaneous ISs were generated by the activation of an identical cortical circuit. Our study suggests that interictal spiking could play a protective role or at least provide an effective restraint against the onset of a focal ictal discharge.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:17:05