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Titolo:
Chronic psychosocial stress differentially affects apoptosis in hippocampal subregions and cortex of the adult tree shrew
Autore:
Lucassen, PJ; Vollmann-Honsdorf, GK; Gleisberg, M; Czeh, B; De Kloet, ER; Fuchs, E;
Indirizzi:
Leiden Univ, LACDR, Div Med Pharmacol, Leiden, Netherlands Leiden Univ Leiden Netherlands , Div Med Pharmacol, Leiden, Netherlands Univ Amsterdam, Swammerdam Inst Life Sci, Fac Sci, Inst Neurobiol, NL-1098SM Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1098 SMM Amsterdam, Netherlands German Primate Ctr, Div Neurobiol, Gottingen, Germany German Primate Ctr Gottingen Germany Div Neurobiol, Gottingen, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 161 - 166
SICI:
0953-816X(200107)14:1<161:CPSDAA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMER-DISEASE; PYRAMIDAL NEURONS; RAT HIPPOCAMPUS; DENTATE GYRUS; HUMAN BRAIN; CELL; CORTICOSTERONE; NEUROGENESIS; DEPRESSION; MORPHOLOGY;
Keywords:
apoptosis; atrophy; chronic stress; cortisol; hippocampus; tree shrew;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Lucassen, PJ Univ Amsterdam, Swammerdam Inst Life Sci, Fac Sci, Inst Neurobiol, Kruislaan 320, NL-1098 SM Amsterdam, Netherlands Univ Amsterdam Kruislaan 320 Amsterdam Netherlands NL-1098 SM
Citazione:
P.J. Lucassen et al., "Chronic psychosocial stress differentially affects apoptosis in hippocampal subregions and cortex of the adult tree shrew", EUR J NEURO, 14(1), 2001, pp. 161-166

Abstract

We studied the effect of chronic psychosocial stress on cell death and volume changes in the tree shrew hippocampus. In situ end labelling (ISEL) identified low frequent but convincing apoptosis in many hippocampal subregions. Also in entorhinal cortex, apoptosis was found, generally at higher frequencies. After 28 days of chronic stress, apoptosis was significantly reduced in the CA1 stratum radiatum, whereas an increase was observed in the hilus (P < 0.04). With all subregions taken together, the hippocampus showed adecrease, whereas in the cortex, an increase in apoptosis was found after stress (P < 0.04). In a parallel and similar chronic stress study, post mortem morphometry of the same brain regions was performed, revealing mild decreases (7.6%) in entire hippocampal volume. We conclude that (i) low frequent apoptosis occurs throughout the adult tree shrew brain, and (ii) 28 daysof chronic stress differentially affects its occurrence in distinct hippocampal subregions and entorhinal cortex. As previous stereological investigations failed to detect any loss in the principal neuronal layers, psychosocial stress, therefore, must affect other (structural) parameters like dendritic tree, interneurons, neurogenesis, or glia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:05:47