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Titolo:
Roles of the glutamate receptor epsilon 2 and delta 2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex
Autore:
Takeuchi, T; Kiyama, Y; Nakamura, K; Tsujita, M; Matsuda, I; Mori, H; Munemoto, Y; Kuriyama, H; Natsume, R; Sakimura, K; Mishina, M;
Indirizzi:
Univ Tokyo, Grad Sch Med, Dept Mol Neurobiol & Pharmacol, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 urobiol & Pharmacol, Tokyo 1130033, Japan Japan Sci & Technol Corp, CREST, Tokyo 1130033, Japan Japan Sci & Technol Corp Tokyo Japan 1130033 CREST, Tokyo 1130033, Japan Kansai Med Univ, Dept Otolaryngol, Osaka 5708507, Japan Kansai Med Univ Osaka Japan 5708507 pt Otolaryngol, Osaka 5708507, Japan Niigata Univ, Inst Brain Res, Dept Cellular Neurobiol, Niigata 9518585, Japan Niigata Univ Niigata Japan 9518585 lar Neurobiol, Niigata 9518585, Japan Japan Sci & Technol Corp, CREST, Niigata 9518585, Japan Japan Sci & Technol Corp Niigata Japan 9518585 T, Niigata 9518585, Japan
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 153 - 160
SICI:
0953-816X(200107)14:1<153:ROTGRE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INBRED MOUSE STRAINS; D-ASPARTATE RECEPTOR; POSTTRAUMATIC-STRESS-DISORDER; RETICULARIS PONTIS CAUDALIS; LONG-TERM POTENTIATION; NMDA RECEPTOR; MICE LACKING; MUTANT MICE; VIETNAM VETERANS; MESSENGER-RNAS;
Keywords:
acoustic startle response; GluR delta 2 subunit; mouse; NMDA receptor GluR epsilon 2 subunit; sensorimotor gating;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Mishina, M Univ Tokyo, Grad Sch Med, Dept Mol Neurobiol & Pharmacol, Tokyo1130033, Japan Univ Tokyo Tokyo Japan 1130033 harmacol, Tokyo 1130033, Japan
Citazione:
T. Takeuchi et al., "Roles of the glutamate receptor epsilon 2 and delta 2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex", EUR J NEURO, 14(1), 2001, pp. 153-160

Abstract

We examined the regulation of the acoustic startle response in mutant miceof the N-methyl-d-aspartate (NMDA)- and delta -subtypes of the glutamate receptor (GluR) channel, which play important roles in neural plasticity in the forebrain and the cerebellum, respectively. Heterozygous mutant mice with reduced GluR epsilon2 subunits of the NMDA receptor showed strongly enhanced startle responses to acoustic stimuli. On the other hand, heterozygousand homozygous mutation of the other NMDA receptor GluR epsilon subunits exerted no, or only small effects on acoustic startle responses. The threshold of the auditory brainstem response of the GluR epsilon2-mutant mice was comparable to that of the wild-type littermates. The primary circuit of theacoustic startle response is a relatively simple oligosynaptic pathway located in the lower brainstem, whilst the expression of GluR epsilon2 is restricted to the forebrain. We thus suggest that the NMDA receptor GluR epsilon2 subunit plays a role in the regulation of the startle reflex. Ablation of the cerebellar Purkinje cell-specific delta2 subunit of the GluR channel exerted little effect on the acoustic startle response but resulted in the enhancement of prepulse inhibition of the reflex. Because inhibition of theacoustic startle response by a weak prepulse is a measure of sensorimotor gating, the process by which an organism filters sensory information, theseobservations indicate the involvement of the cerebellum in the modulation of sensorimotor gating.

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Documento generato il 19/01/20 alle ore 20:17:41