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Titolo:
BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipsychotic drugs
Autore:
Lipska, BK; Khaing, ZZ; Weickert, CS; Weinberger, DR;
Indirizzi:
NIMH, Clin Brain Disorders Branch, Intramural Res Program, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 Intramural Res Program, Bethesda, MD 20892 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 135 - 144
SICI:
0953-816X(200107)14:1<135:BMEIRH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; CHRONIC HALOPERIDOL TREATMENT; NEUROTROPHIC FACTOR; ANTEROGRADE TRANSPORT; SYNAPTIC TRANSMISSION; GLUTAMATE RECEPTORS; REPEATED STRESS; BRAIN; DOPAMINE; SCHIZOPHRENIA;
Keywords:
animal model; clozapine; haloperidol; neurotrophin; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Lipska, BK NIMH, Clin Brain Disorders Branch, Intramural Res Program, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 Res Program, Bethesda, MD 20892 USA
Citazione:
B.K. Lipska et al., "BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipsychotic drugs", EUR J NEURO, 14(1), 2001, pp. 135-144

Abstract

Brain-derived neurotrophic factor (BDNF) plays an important role in development, synapse remodelling and responses to stress and injury. Its abnormalexpression has been implicated in schizophrenia, a neuropsychiatric disorder in which abnormal neural development of the hippocampus and prefrontal cortex has been postulated. To clarify the effects of antipsychotic drugs used in the therapy of schizophrenia on BDNF mRNA, we studied its expression in rats treated with clozapine and haloperidol and in rats with neonatal lesions of the ventral hippocampus, used as an animal model of schizophrenia. Both antipsychotic drugs reduced BDNF expression in the hippocampus of control rats, but did not significantly lower its expression in the prefrontalcortex. The neonatal hippocampal lesion itself suppressed BDNF mRNA expression in the dentate gyrus and tended to reduce its expression in the prefrontal cortex. These results indicate that, unlike antidepressants, antipsychotics down-regulate BDNF mRNA, and suggest that their therapeutic properties are not mediated by stimulation of this neurotrophin. To the extent that the lesioned rat models some pathophysiological aspects of schizophrenia, our data suggest that a neurodevelopmental insult might suppress expression of the neurotrophin in certain brain regions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:34:40