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Titolo:
Antisense oligodeoxynucleotide-induced suppression of basal forebrain NMDA-NR1 subunits selectively impairs visual attentional performance in rats
Autore:
Turchi, J; Sarter, M;
Indirizzi:
Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 ept Psychol, Columbus, OH 43210 USA Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 pt Neurosci, Columbus, OH 43210 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 103 - 117
SICI:
0953-816X(200107)14:1<103:AOSOBF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL ACETYLCHOLINE-RELEASE; COGNITIVE FUNCTIONS; NUCLEUS BASALIS; FLUORO-JADE; CHOLINERGIC SYSTEMS; NEURAL MECHANISMS; DIVIDED ATTENTION; CORTEX; MODULATION; OLIGONUCLEOTIDES;
Keywords:
acetylcholine; antisense oligodeoxynucleotides; attention; basal forebrain; glutamate; NMDA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Sarter, M Ohio State Univ, Dept Psychol, 27 Townshend Hall, Columbus, OH 43210 USA Ohio State Univ 27 Townshend Hall Columbus OH USA 43210 3210 USA
Citazione:
J. Turchi e M. Sarter, "Antisense oligodeoxynucleotide-induced suppression of basal forebrain NMDA-NR1 subunits selectively impairs visual attentional performance in rats", EUR J NEURO, 14(1), 2001, pp. 103-117

Abstract

It is generally agreed that basal forebrain neuronal circuits contribute to the mediation of the ability to detect, select and discriminate signals, to suppress the processing of irrelevant information, and to allocate processing resources to competing tasks. Rats were trained in a task designed toassess sustained attention, or in a cued discrimination task that did not tax attentional processes. Animals were equipped with guide cannula to infuse bilaterally antisense oligodeoxynucleotides (ODNs) against the N-methyl-d-aspartate (NMDA) NR1 subunits, or missense ODNs, into the substantia innominata of the basal forebrain. Infusions of antisense or missense ODNs did not affect cued visual discrimination performance. Infusions of antisense ODNs dose-dependently impaired sustained attention performance by selectively decreasing the animals' ability to detect signals while their ability to reject nonsignal trials remained unchanged. The detrimental attentional effects of antisense infusions were maximal 24 h after the third and final infusion, and performance returned to baseline 24 h later. Missense infusions did not affect attentional performance. Separate experiments demonstrated extensive suppression of NR1 subunit immunoreactivity in the substantia innominata. Furthermore, infusions of antisense did not produce neurotoxic effects in that region as demonstrated by the Fluoro-Jade method. The present data support the hypothesis that NMDA receptor (NMDAR) stimulation in the basal forebrain, largely via glutamatergic inputs originating in the prefrontal cortex, represents a necessary mechanism to activate the basal forebraincorticopetal system for mediation of attentional performance.

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Documento generato il 28/01/20 alle ore 16:02:51