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Titolo:
Effects of cannabinoids on prefrontal neuronal responses to ventral tegmental area stimulation
Autore:
Pistis, M; Porcu, G; Melis, M; Diana, M; Gessa, GL;
Indirizzi:
Univ Cagliari, BB Brodie Dept Neurosci, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 t Neurosci, I-09124 Cagliari, Italy Univ Sassari, Dept Drug Sci, I-07100 Sassari, Italy Univ Sassari SassariItaly I-07100 Dept Drug Sci, I-07100 Sassari, Italy
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 96 - 102
SICI:
0953-816X(200107)14:1<96:EOCOPN>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPAIRS SPATIAL MEMORY; CB1 RECEPTORS; DOPAMINE NEURONS; IN-VIVO; PHARMACOLOGICAL CHARACTERIZATION; GABAERGIC INTERNEURONS; CORTICAL-NEURONS; AXON TERMINALS; RAT; CORTEX;
Keywords:
electrophsiology; mesocortical dopamine system; pyramidal cells; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Pistis, M Univ Cagliari, BB Brodie Dept Neurosci, Via Porcell 4, I-09124 Cagliari, Italy Univ Cagliari Via Porcell 4 Cagliari Italy I-09124 liari, Italy
Citazione:
M. Pistis et al., "Effects of cannabinoids on prefrontal neuronal responses to ventral tegmental area stimulation", EUR J NEURO, 14(1), 2001, pp. 96-102

Abstract

Cannabinoids activate the firing of mesoprefrontocortical dopamine neuronsand release dopamine in the prefrontal cortex. This study was undertaken with the aim of clarifying the interaction between cannabinoids and mesocortical system in the prefrontal cortex. The effect of Delta (9)-tetrahydrocannabinol (Delta (9)-THC) and the synthetic CB1 agonist WIN55,212-2 (WIN) wasstudied by extracellular single unit recordings, in chloral hydrate anaesthetised rats, on the spontaneous activity of pyramidal neurons and on the inhibition produced on these neurons by the electrical stimulation of the ventral tegmental area (VTA). Intravenously administered Delta (9)-THC and WIN (1.0 and 0.5 mg/kg, respectively), increased the firing rate of pyramidalneurons projecting to the VTA. VTA stimulation produced a phasic inhibition (167 +/- 6 ms) in 79% of prefrontal cortex pyramidal neurons. Delta (9)-THC and WIN reverted this inhibition in 73% and 100% of the neurons tested, respectively. The subsequent administration of the selective CB1 antagonistSR141716A (1 mg/kg) readily suppressed the effects of both cannabinoids and restored the inhibitory response to VTA stimulation. Moreover, when administered alone, SR141716A prolonged the inhibition in 55.6% of the neurons tested. The results indicate that stimulation of CB1 receptors by cannabinoids results in an enhanced excitability of prefrontal cortex pyramidal neurons as indexed by the suppression of the inhibitory effect of VTA stimulation and by the increase in firing rate of antidromically identified neurons projecting to the VTA. Furthermore, our results support the view that endogenous cannabinoids exert a negative control on dopamine activity in the prefrontal cortex. This study may be relevant in helping to understand the influence of cannabinoids on cognitive processes mediated by the prefrontal cortex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:43:38