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Titolo:
Chronic levodopa therapy does not improve skilled reach accuracy or reach range on a pasta matrix reaching task in 6-OHDA dopamine-depleted (hemi-Parkinson analogue) rats
Autore:
Metz, GAS; Farr, T; Ballermann, M; Whishaw, IQ;
Indirizzi:
Univ Lethbridge, Dept Psychol & Neurosci, Lethbridge, AB T1K 3M4, Canada Univ Lethbridge Lethbridge AB Canada T1K 3M4 thbridge, AB T1K 3M4, Canada
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 27 - 37
SICI:
0953-816X(200107)14:1<27:CLTDNI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANTIA-NIGRA; GRASP MOVEMENT; FORELIMB USE; LIMB USE; 6-HYDROXYDOPAMINE LESIONS; COMPENSATORY ADJUSTMENTS; MAGNETIC STIMULATION; MOTOR ASYMMETRY; STRIATAL GRAFTS; RICH GRAFTS;
Keywords:
animal model; rotational behaviour; unilateral nigrostriatal bundle lesion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Metz, GAS Univ Lethbridge, Dept Psychol & Neurosci, 4401 Univ Dr, Lethbridge, AB T1K3M4, Canada Univ Lethbridge 4401 Univ Dr Lethbridge AB Canada T1K3M4 Canada
Citazione:
G.A.S. Metz et al., "Chronic levodopa therapy does not improve skilled reach accuracy or reach range on a pasta matrix reaching task in 6-OHDA dopamine-depleted (hemi-Parkinson analogue) rats", EUR J NEURO, 14(1), 2001, pp. 27-37

Abstract

L-dopa therapy reverses some but not all of the motor deficits in human Parkinson patients. Although a number rat analogues of human Parkinson's disease have been developed for evaluating the efficacy of drug therapies, it is not known whether L-dopa has a similar selective action on the motor symptoms in the rat models. To examine the effectiveness of L-dopa in reversingthe motor deficits in rats, we administered 6-OHDA unilaterally to producehemi-Parkinson rats, which were then trained to reach for food using either their impaired (contralateral to the lesion) limb or their good (ipsilateral to the lesion) limb. To assess the skill, accuracy and range of limb movement, rats reached for pasta from a horizontal array of 260 vertically orientated pieces of pasta. The number and location of pasta pieces taken from this matrix was calculated and the qualitative aspects of the reaching movements were rated. The quantitative data on pasta sticks retrieved indicated that forelimb extension and movement radius around the shoulder joint was reduced by 6-OHDA treatment and did not improve after chronic L-dopa treatment. The qualitative analysis showed that grasping patterns, paw movements and body movements impaired by the lesion were also not improved by L-dopa treatment. These findings are the first in the rat to suggest that whereas L-dopa has a general activating effect on the rat's whole-body movements,as displayed in contralateral rotation, its effectiveness does not extend to skilled forelimb movements. The results are discussed in relationship tothe idea that the restoration of some skilled movements may require normalsynaptic function.

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Documento generato il 19/01/20 alle ore 09:14:13