Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Non-alcoholic steatohepatitis induced by carbamazepine and variegate porphyria
Autore:
Grieco, A; Alfei, B; Di Rocco, P; Miele, L; Biolcati, G; Griso, D; Vecchio, FM; Bianco, A; Gasbarrini, G;
Indirizzi:
Univ Sacred Heart, Fac Med A Gemelli, Ist Med Interna & Geriatria, I-00168Rome, Italy Univ Sacred Heart Rome Italy I-00168 rna & Geriatria, I-00168Rome, Italy
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 8, volume: 13, anno: 2001,
pagine: 973 - 975
SICI:
0954-691X(200108)13:8<973:NSIBCA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
REACTIVE METABOLITES; P450;
Keywords:
carbamazepine; drug adverse reaction; drug-induced liver disease; epilepsy; non-alcoholic steatohepatitis; porphyria; toxic hepatitis; variegate porphyria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Grieco, A Univ Sacred Heart, Fac Med A Gemelli, Ist Med Interna & Geriatria, Largo Gemelli 8, I-00168 Rome, Italy Univ Sacred Heart Largo Gemelli 8 Rome Italy I-00168 ome, Italy
Citazione:
A. Grieco et al., "Non-alcoholic steatohepatitis induced by carbamazepine and variegate porphyria", EUR J GASTR, 13(8), 2001, pp. 973-975

Abstract

A 42-year-old woman presented with acute bullous skin lesions and angio-oedema that had developed 3 months after initiation of treatment with carbamazepine for epilepsy. Chromatographic analysis of urinary porphyrins was compatible with variegate porphyria. This was manifested initially by neurological symptoms that were mistaken for epilepsy and later by cutaneous symptoms also. Histological findings excluded hepatic porphyria, but revealed severe fatty changes thought to be caused by idiosyncratic metabolism of carbamazepine. While the porphyrinogenicity of carbamazepine is well known, the presence of variegate porphyria has not been reported. The toxic hepatic effects of the drug on hepatic cytochrome P-450, which is involved in haem metabolism, could have aggravated the pre-existent porphyria, provoking the onset of skin lesions. Eur J Gastroenterol Hepatol 13:973-975 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 22:57:25