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Titolo:
Butyrate and propionate downregulate ERK phosphorylation in HT-29 colon carcinoma cells prior to differentiation
Autore:
Davido, DJ; Richter, F; Boxberger, F; Stahl, A; Menzel, T; Luhrs, H; Loffler, S; Dusel, G; Rapp, UR; Scheppach, W;
Indirizzi:
Univ Wurzburg, Med Klin, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 d Klin, D-97080 Wurzburg, Germany Univ Wurzburg, Inst Med Strahlenkunde & Zellforsch, D-97078 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97078 forsch, D-97078 Wurzburg, Germany
Titolo Testata:
EUROPEAN JOURNAL OF CANCER PREVENTION
fascicolo: 4, volume: 10, anno: 2001,
pagine: 313 - 321
SICI:
0959-8278(200108)10:4<313:BAPDEP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHAIN FATTY-ACIDS; SODIUM-BUTYRATE; PROTEIN-KINASE; HISTONE MODIFICATION; MYC EXPRESSION; DNA-BINDING; GROWTH; LINE; GENE; METHYLATION;
Keywords:
adenocarcinoma; butyrate; extracellular signal-regulated kinases; HT-29 cells; propionate; short-chain fatty acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Scheppach, W Univ Wurzburg, Med Klin, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080
Citazione:
D.J. Davido et al., "Butyrate and propionate downregulate ERK phosphorylation in HT-29 colon carcinoma cells prior to differentiation", EUR J CAN P, 10(4), 2001, pp. 313-321

Abstract

We have characterized the effects of different short-chain fatty acids (SCFAs) on cell growth and differentiation as well as the phosphorylation state of ERK1 and 2 in the human colon adenocarcinoma cell line HT-29. Of the five SCFAs tested, only butyrate and propionate impaired cellular proliferation. Moreover, butyrate and propionate specifically resulted in a decrease in ERK1 and 2 phosphorylation at 3 and 6 hours post-treatment, suggesting acorrelation between the ability of these SCFAs to inhibit cellular proliferation and decrease ERK phosphorylation. Notably, the decrease in ERK phosphorylation was observed prior to the induction of the differentiation markers alkaline phosphatase (AP) and carcinoembryonic antigen (CEA) by butyrateand propionate from days 6 to 18 post-treatment. In the case of butyrate- and propionate-induced differentiation, ERK phosphorylation is a marker andmay play a role in the proliferation and/or differentiation states of thiscell line. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 09/04/20 alle ore 20:09:56