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Titolo:
The relative importance of proliferation and cell death in breast cancer growth and response to tamoxifen
Autore:
Cameron, DA; Ritchie, AA; Miller, WR;
Indirizzi:
Univ Edinburgh, Dept Oncol, Edinburgh Breast Res Unit, Edinburgh, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland burgh, Midlothian, Scotland Western Gen Hosp, Imperial Canc Res Fund, Med Oncol Unit, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Edinburgh Midlothian Scotland EH42XU dlothian, Scotland
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 12, volume: 37, anno: 2001,
pagine: 1545 - 1553
SICI:
0959-8049(200108)37:12<1545:TRIOPA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATHEMATICAL-MODELS; APOPTOSIS; CARCINOMAS; PROGNOSIS; KINETICS; BCL-2;
Keywords:
apoptosis; breast cancer; Gompertz; tamoxifen; xenograft;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Cameron, DA Univ Edinburgh, Dept Oncol, Edinburgh Breast Res Unit, Edinburgh, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland thian, Scotland
Citazione:
D.A. Cameron et al., "The relative importance of proliferation and cell death in breast cancer growth and response to tamoxifen", EUR J CANC, 37(12), 2001, pp. 1545-1553

Abstract

Changes in tumour volume depend on the relative balance between cell proliferation and cell loss. However, these processes are not independent, and it remains unclear which is more important in tumour progression and regression. For example, the antioestrogen tamoxifen, a mainstay in the therapy ofbreast cancer, has both antiproliferative and pro-apoptotic actions, and their relative importance in clinical efficacy is unknown. Thus, using a model system based on oestrogen receptor (ER)-positive ZR-75-1 breast cancer xenografts, both increased apoptosis and reduced proliferation have been previously shown to occur within 7 days of tamoxifen therapy (Cameron DA, Ritchie AA, Langdon S, Anderson TJ, Miller WR. Tamoxifen induced apoptosis in ZR-75 breast cancer xenografts antedates tumour regression. Breast Cancer Res Treat 1997, 45, 99-107). In the present,study, Gompertzian growth curves have been fitted to individual breast cancer xenografts. This demonstrates that the growth rate of the untreated tumours is directly dependent only onthe mitotic rate (P <0.001), whereas tumour response to tamoxifen correlates most strongly (P <0.001) with the relative balance between apoptosis andmitosis, as evidenced by the apoptotic: mitotic ratio. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:30:27