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Titolo:
Time trends in the results of breast conservation in 4694 women
Autore:
Fredriksson, I; Liljegren, G; Arnesson, LG; Emdin, SO; Palm-Sjovall, M; Fornander, T; Frisell, J; Holmberg, L;
Indirizzi:
Stockholm Soder Hosp, Dept Surg, Karolinska Inst, Stockholm, Sweden Stockholm Soder Hosp Stockholm Sweden arolinska Inst, Stockholm, Sweden Univ Uppsala Hosp, Reg Oncol Ctr, Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden a Hosp, Reg Oncol Ctr, Uppsala, Sweden Huddinge Univ Hosp, Dept Surg, Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden Hosp, Dept Surg, Stockholm, Sweden Stockholm Soder Hosp, Dept Oncol, Stockholm, Sweden Stockholm Soder Hosp Stockholm Sweden sp, Dept Oncol, Stockholm, Sweden Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 osp, Dept Oncol, S-22185 Lund, Sweden Univ Lund Hosp, Dept Surg, Umea, Sweden Univ Lund Hosp Umea SwedenUniv Lund Hosp, Dept Surg, Umea, Sweden Linkoping Univ Hosp, Dept Biomed & Surg, S-58185 Linkoping, Sweden Linkoping Univ Hosp Linkoping Sweden S-58185 , S-58185 Linkoping, Sweden Orebro Med Ctr Hosp, Ctr Assessment Med Technol Orebro, S-70185 Orebro, Sweden Orebro Med Ctr Hosp Orebro Sweden S-70185 Orebro, S-70185 Orebro, Sweden Orebro Med Ctr Hosp, Dept Surg, S-70185 Orebro, Sweden Orebro Med Ctr Hosp Orebro Sweden S-70185 t Surg, S-70185 Orebro, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 12, volume: 37, anno: 2001,
pagine: 1537 - 1544
SICI:
0959-8049(200108)37:12<1537:TTITRO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAGE-I; POSTOPERATIVE RADIOTHERAPY; RANDOMIZED TRIAL; CONSERVING TREATMENT; PREMENOPAUSAL WOMEN; AXILLARY DISSECTION; SECTOR RESECTION; CANCER; MAMMOGRAPHY; SURGERY;
Keywords:
breast cancer; conservative treatment; cohort study; local recurrence; radiotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Fredriksson, I Stockholm Soder Hosp, Dept Surg, Karolinska Inst, Stockholm, Sweden Stockholm Soder Hosp Stockholm Sweden Stockholm, Sweden
Citazione:
I. Fredriksson et al., "Time trends in the results of breast conservation in 4694 women", EUR J CANC, 37(12), 2001, pp. 1537-1544

Abstract

In a population-based cohort of 4694 women with invasive breast cancer, operated upon with breast conserving surgery (BCS) in 1981-1990 and followed through to 1997, we studied how this technique had been adopted into clinical practice, especially with reference to the use of radiotherapy (RT). Ourmain aim was to see whether there was a drift in the risk of local recurrence and breast cancer death over time. During the 30 151 person-years of observation in the cohort, there were 582 local recurrences, 456 breast cancer deaths and 438 deaths due to other causes. Postoperative RT was given to 70.2%, but usage increased over the period. The women not receiving RT weremostly elderly, but also in women < 70 years, 20.4% did not receive RT. The risk for local recurrence after RT were 7.6 and 17.8% at 5 and 10 years, respectively. Without RT, more than 30% had a local recurrence at 10 years. Thus, the choice not to irradiate failed to target women at a low risk. Ina multivariate Cox analysis taking tumour size, nodal status, age at operation and RT into account, there was a trend for a higher risk of local recurrence in the later time period, relative hazard 1.5 (95% confidence interval (CI) 1.0-2.1). Corrected survival was 93.3 and 85.2% at 5 and 10 years, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 19:48:02