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Titolo:
The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation
Autore:
Swanton, BJ; Iohom, G; Wang, JH; Redmond, HP; Shorten, GD;
Indirizzi:
Cork Univ Hosp, Dept Anaesthesia & Intens Care Med, Cork, Ireland Cork Univ Hosp Cork Ireland naesthesia & Intens Care Med, Cork, Ireland Cork Univ Hosp, Dept Surg, Cork, Ireland Cork Univ Hosp Cork IrelandCork Univ Hosp, Dept Surg, Cork, Ireland
Titolo Testata:
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
fascicolo: 8, volume: 18, anno: 2001,
pagine: 524 - 529
SICI:
0265-0215(200108)18:8<524:TEOLON>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN POLYMORPHONUCLEAR LEUKOCYTES; BACTERIAL PEPTIDE FMLP; OXIDATIVE RESPONSE; IN-VITRO; ANESTHETIC AGENTS; NITROUS-OXIDE; LARYNGOSCOPY; ALFENTANIL; ENFLURANE; MIDAZOLAM;
Keywords:
anaesthetics, intravenous, thiopental, anaesthetics, local, amide, lidocaine; cell physiology, cell respiration, respiratory burst; immune system, leucocytes, granulocytes, neutrophils;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Swanton, BJ Massachusetts Gen Hosp, Dept Anaesthesia & Crit Care, 55 FruitSt, Boston,MA 02114 USA Massachusetts Gen Hosp 55 Fruit St Boston MA USA 02114 114 USA
Citazione:
B.J. Swanton et al., "The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation", EUR J ANAES, 18(8), 2001, pp. 524-529

Abstract

Background and objective Respiratory burst is an essential component of the neutrophil's biocidal function. In vitro, sodium thiopental, isoflurane and lidocaine each inhibit neutrophil respiratory burst. The objectives of this study were (a) to determine the effect of a standard clinical induction/tracheal intubation sequence on neutrophil respiratory burst and (b) to determine the effect of intravenous lidocaine administration during inductionof anaesthesia on neutrophil respiratory burst. Methods Twenty ASA I and II patients, aged 18-60 years, undergoing elective surgery were studied. After induction of anaesthesia [fentanyl (2 mug kg(-1)), thiopental (4-6 mg kg(-1)), isoflurane (end-tidal concentration 0.5-1.5%) in nitrous oxide (66%) and oxygen], patients randomly received either lidocaine 1.5 mg kg(-1) (group L) or 0.9% saline (group S) prior to tracheal intubation. Neutrophil respiratory burst was measured immediately prior to induction of anaesthesia, immediately before and 1 and 5 min after lidocaine/saline. Results Neutrophil respiratory burst decreased significantly after induction of anaesthesia in both groups [87.4 +/- 8.2% (group L) and 88.5 +/- 13.4% (group S) of preinduction level (P < 0.01 both groups)]. After intravenous lidocaine (but not saline) administration, neutrophil respiratory burst returned towards preinduction levels, both before (97.1 +/- 23.6%) and after(94.4 +/- 16.6%) tracheal intubation. Conclusion Induction of anaesthesia and tracheal intubation using thiopentone and isoflurane, inhibit neutrophil respiratory burst. This effect may be diminished by the administration of lidocaine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 08:06:04