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Titolo:
Serum concentration of androstenediol and androstenediol sulfate in patients with hyperthyroidism and hypothyroidism
Autore:
Tagawa, N; Takano, T; Fukata, S; Kuma, K; Tada, H; Izumi, Y; Kobayashi, Y; Amino, N;
Indirizzi:
Kobe Pharmaceut Univ, Clin Chem Lab, Higashinada Ku, Kobe, Hyogo 6588558, Japan Kobe Pharmaceut Univ Kobe Hyogo Japan 6588558 Kobe, Hyogo 6588558, Japan Osaka Univ, Sch Med, Dept Lab Med, Suita, Osaka 5650871, Japan Osaka UnivSuita Osaka Japan 5650871 Lab Med, Suita, Osaka 5650871, Japan Kuma Hosp, Chuo Ku, Kobe, Hyogo 6500011, Japan Kuma Hosp Kobe Hyogo Japan6500011 p, Chuo Ku, Kobe, Hyogo 6500011, Japan
Titolo Testata:
ENDOCRINE JOURNAL
fascicolo: 3, volume: 48, anno: 2001,
pagine: 345 - 354
SICI:
0918-8959(200106)48:3<345:SCOAAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-TESTICULAR AXIS; DEHYDROEPIANDROSTERONE-SULFATE; IMMUNE-RESPONSE; ENZYME-IMMUNOASSAY; BREAST-CANCER; NORMAL MEN; METABOLISM; WOMEN; BINDING; PLASMA;
Keywords:
androstenediol (ADIOL); ADIOL sulfate; dehydroepiandrosterone (DHEA); DHEA sulfate; thyroid dysfunction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Kobayashi, Y Kobe Pharmaceut Univ, Clin Chem Lab, Higashinada Ku, 4-19-1 Motoyamakita Machi, Kobe, Hyogo 6588558, Japan Kobe Pharmaceut Univ 4-19-1 Motoyamakita Machi Kobe Hyogo Japan 6588558
Citazione:
N. Tagawa et al., "Serum concentration of androstenediol and androstenediol sulfate in patients with hyperthyroidism and hypothyroidism", ENDOCR J, 48(3), 2001, pp. 345-354

Abstract

Androstenediol (5-androsten-3 beta, 17 beta -diol, ADIOL) and androstenediol 3-sulfate (ADIOLS) are active metabolites of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS), respectively, and have estrogenic activity andimmunoregulatory function. We examined serum concentrations of ADIOL, ADIOLS, DHEA, DHEAS and pregnenolone sulfate (5-pregnen-3 beta -ol-20-one sulfate, PREGS) in patients with Graves' thyrotoxicosis (male/female 9/14), hypothyroidism (11/20) and in normal controls (14/29). In hypothyroidism serum levels of all these steroids were significantly decreased in both genders. In hyperthyroidism, in contrast, serum levels of ADIOLS (male 1.49 +/-0.69,female 0.64 +/-0.31 mu mol/l), DHEAS (male 7.43 +/-3.91, female 5.13 +/-2.03 mu mol/l), and PREGS (male 1.13 +/-0.58, female 1.07 +/-0.85 mu mol/l) were markedly increased, but serum concentrations of ADIOL and DEHA were notsignificantly different from controls (ADIOLS male 0.36 +/-0.33, female 0.14 +/-0.09 mu mol/l; DHEAS male 2.88 +/-1.70, female 1.86 +/-1.03 mu mol/l;PREGS male 0.18 +/-0.12, female 0.11 +/-0.08 mu mol/l; ADIOL male 3.76 +/-1.35, female 1.91 +/-1.17 nmol/l; DHEA male 9.23 +/-3.49, female 13.5 +/- 10.8 nmol/l). Serum concentrations of all these steroids correlated with theserum concentration of the thyroid hormones in these patients. Serum albumin and sex hormone-binding globulin concentrations were not related to these changes in the concentrations of steroids. These findings indicate that serum concentrations of ADIOLS, ADIOL, DHEAS, DHEA and PREGS were decreased in hypothyroidism, whereas serum ADIOLS, DHEAS and PREGS concentrations were increased but ADIOL and DHEA were normal in hyperthyroidism. Thyroid hormone may stimulate the synthesis of these steroids and sulfotransferase is speculated to be increased in hyperthyroidism. Increased ADIOLS might contribute to menstrual disturbances and gynecomastia in hyperthyroidism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:48:56