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Titolo:
Pharmacogenetics of the human drug-transporter gene MDR1: impact of polymorphisms on pharmacotherapy
Autore:
Brinkmann, U; Roots, I; Eichelbaum, M;
Indirizzi:
Epidauros Biotechnol Pharmacogenet Labs, D-82347 Bernried, Germany Epidauros Biotechnol Pharmacogenet Labs Bernried Germany D-82347 Germany Univ Med Ctr Charite, Inst Clin Pharmacol, D-10117 Berlin, Germany Univ Med Ctr Charite Berlin Germany D-10117 col, D-10117 Berlin, Germany Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-70376 Stuttgart, GermanyDr Margarete Fischer Bosch Inst Clin Pharmacol Stuttgart Germany D-70376
Titolo Testata:
DRUG DISCOVERY TODAY
fascicolo: 16, volume: 6, anno: 2001,
pagine: 835 - 839
SICI:
1359-6446(20010815)6:16<835:POTHDG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIDRUG-RESISTANCE PROTEIN; BLOOD-BRAIN-BARRIER; INTESTINAL P-GLYCOPROTEIN; CYCLOSPORINE-A; ALTERED PHARMACOKINETICS; ORAL BIOAVAILABILITY; CATIONIC DRUGS; BINDING SITES; MICE; VINBLASTINE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Brinkmann, U Epidauros Biotechnol Pharmacogenet Labs, Am Neuland 1, D-82347 Bernried, Germany Epidauros Biotechnol Pharmacogenet Labs Am Neuland 1 Bernried Germany D-82347
Citazione:
U. Brinkmann et al., "Pharmacogenetics of the human drug-transporter gene MDR1: impact of polymorphisms on pharmacotherapy", DRUG DISC T, 6(16), 2001, pp. 835-839

Abstract

The blood- and tissue-concentrations, and thus the activity, of many drugsare influenced by factors that are subject to inter-individual variation. Variables that influence blood levels are metabolizing enzymes and transporters. Transporters control drug uptake, distribution and elimination. Transport by efflux pumps such as MDR1-encoded P-glycoprotein can influence the bioavailability of drugs. Knowledge of the transporter 'status' might allowfor compensation of differences in drug uptake, such as by dose adjustment, which is important for drugs with narrow therapeutic windows. So far, intestinal expression of MDR1 has been determined by cumbersome methods, such as biopsies, although recently a functional polymorphism has been identified, which discriminates individual high or low-expressor alleles. As a result, clinical trials and therapy can be adapted to the 'MDR1-status' of individual patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:25:25