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Titolo:
Expression of proinflammatory cytokines and their inhibitors during the course of spontaneous bacterial peritonitis
Autore:
Rodriguez-Ramos, C; Galan, F; Diaz, F; Elvira, J; Martin-Herrera, L; Giron-Gonzalez, JA;
Indirizzi:
Hosp Univ Puerta Mar, Internal Med Serv, Cadiz 11003, Spain Hosp Univ Puerta Mar Cadiz Spain 11003 rnal Med Serv, Cadiz 11003, Spain Hosp Univ Puerta Mar, Digest Dis Serv, Cadiz, Spain Hosp Univ Puerta Mar Cadiz Spain rta Mar, Digest Dis Serv, Cadiz, Spain Hosp Univ Puerta Mar, Microbiol Serv, Cadiz, Spain Hosp Univ Puerta Mar Cadiz Spain erta Mar, Microbiol Serv, Cadiz, Spain
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 8, volume: 46, anno: 2001,
pagine: 1668 - 1676
SICI:
0163-2116(200108)46:8<1668:EOPCAT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CIRRHOTIC-PATIENTS; FACTOR RECEPTOR; ASCITIC FLUID; NITRIC-OXIDE; FACTOR-ALPHA; EXPERIMENTAL ENDOTOXEMIA; CEREBROSPINAL-FLUID; SOLUBLE RECEPTORS; RENAL IMPAIRMENT;
Keywords:
liver cirrhosis; spontaneous bacterial peritonitis; interleukin 1; interleukin 1 receptor antagonist; tumor necrosis factor alpha; tumor necrosis factor alpha receptors; interleukin 6; interleukin 6 receptor; interleukin 10;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Giron-Gonzalez, JA Hosp Univ Puerta Mar, Internal Med Serv, Ave Ana de Viya 21, Cadiz 11003, Spain Hosp Univ Puerta Mar Ave Ana de Viya 21 Cadiz Spain 11003
Citazione:
C. Rodriguez-Ramos et al., "Expression of proinflammatory cytokines and their inhibitors during the course of spontaneous bacterial peritonitis", DIG DIS SCI, 46(8), 2001, pp. 1668-1676

Abstract

The aim of this work was the evaluation, in cirrhotic patients with noninfected ascites and with spontaneous bacterial peritonitis (SBP), of serum and ascitic fluid levels of proinflammatory cytokines [interleukin (IL) 1-beta, tumor necrosis factor alpha (TNF-alpha), and IL6] and antiinflammatory compounds [ILIO, soluble IL-I receptor antagonist (sIL-1Ra), soluble receptors of TNF p55 and p75 (sTNFR55 and sTNFR75), and soluble receptor of IL6 (sIL6R)], as well as their relationship with the outcome of the infection in those with SBP. These molecules were assayed by ELISA in noninfected cirrhotic controls (n = 15), patients with SBP (n = 32), and healthy controls (n = 20). Serum levels of IL6 and of the majority of antiinflammatory mediators, sIL1Ra, sTNFR75, and sIL6R, were higher in control cirrhotic patients compared to healthy subjects. SBP was associated with significantly elevated ascitic fluid levels of every one of the proinflammatory cytokines comparedto those in cirrhotic controls. Also, serum levels of IL10 and both TNF receptors and ascitic fluid levels of sIL1 Ra and sTNFR55 were higher in patients with SBP compared to cirrhotic controls. Ascitic fluid levels of proinflammatory cytokines decreased rapidly after resolution of the infection; however, nonsignificant changes were detected in ascitic fluid concentrations of antiinflammatory molecules. Thus, elevated levels of antiinflammatory compounds both in noninfected cirrhotic patients and in patients with SBP suggest a regulatory control of the inflammatory process by these molecules in liver cirrhosis patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:39:55