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Titolo:
Bid regulation of neuronal apoptosis
Autore:
Leonard, JR; DSa, C; Cahn, BR; Korsmeyer, SJ; Roth, KA;
Indirizzi:
Washington Univ, Sch Med, Dept Pathol & Immunol, Div Neuropathol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Neuropathol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Neurol Surg, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Neurol Surg, St Louis, MO 63110 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pathol & Med,Howard Hughes Med Inst, Pittsburgh, PA 15261 USA Harvard Univ Pittsburgh PA USA 15261 s Med Inst, Pittsburgh, PA 15261 USA
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 128, anno: 2001,
pagine: 187 - 190
SICI:
0165-3806(20010629)128:2<187:BRONA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-C RELEASE; NF-KAPPA-B; CELL-DEATH; CASPASE ACTIVATION; NERVOUS-SYSTEM; DEFICIENT MICE; BH3 DOMAIN; MITOCHONDRIA; PREVENTS;
Keywords:
programmed cell death; Bcl-2; Bcl-X-L;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Roth, KA Washington Univ, Sch Med, Dept Pathol & Immunol, Div Neuropathol,660 S Euclid Ave Box 8118, St Louis, MO 63110 USA Washington Univ 660 S Euclid Ave Box 8118 St Louis MO USA 63110 A
Citazione:
J.R. Leonard et al., "Bid regulation of neuronal apoptosis", DEV BRAIN R, 128(2), 2001, pp. 187-190

Abstract

Bid is a BH3 domain only pro-apoptotic member of the Bcl-2 family which interacts with Ba-x to regulate apoptosis. Bax-deficient embryos show decreased neuronal programmed cell death in vivo and resistance to cytosine arabinoside (AraC)-induced neuronal apoptosis in vitro. In this report, we demonstrate that Bid-deficient embryos show no neurodevelopmental abnormalities, and Bid-deficiency has no effect on the in vitro apoptotic response of either telencephalic neural precursor cells or neurons to AraC-induced death. We conclude that bid does not play an essential role in either naturally occurring or genotoxin-induced neuronal cell death. (C) 2001 Elsevier Science BY All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:20:42