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Titolo:
RELIABILITY OF AN INSTRUMENTAL ASSESSMENT OF TARDIVE-DYSKINESIA - RESULTS FROM VA COOPERATIVE STUDY NUMBER-394
Autore:
CALIGIURI MP; LOHR JB; ROTROSEN J; ADLER L; LAVORI P; EDSON R; TRACY K;
Indirizzi:
SAN DIEGO VA MED CTR,MOTOR FUNCT LAB,GERIATR PSYCHIAT CLIN RES CTR,V-116A1 SAN DIEGO CA 92161 SAN DIEGO VA MED CTR,PSYCHIAT SERV 116A SAN DIEGO CA 92161 VET ADM MED CTR,PSYCHIAT SERV 116A NEW YORK NY 10010 VA PALO ALTO HLTH CARE SYST,CSPCC 151K PALO ALTO CA 94304
Titolo Testata:
Psychopharmacology
fascicolo: 1, volume: 132, anno: 1997,
pagine: 61 - 66
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; MULTICENTER; SCALE; PATIENT; TRIAL;
Keywords:
TARDIVE DYSKINESIA; INSTRUMENTATION; MULTICENTER STUDY; ANTIOXIDANT; INTERRATER RELIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.P. Caligiuri et al., "RELIABILITY OF AN INSTRUMENTAL ASSESSMENT OF TARDIVE-DYSKINESIA - RESULTS FROM VA COOPERATIVE STUDY NUMBER-394", Psychopharmacology, 132(1), 1997, pp. 61-66

Abstract

Nine VA Medical Centers are participating in a 2-year double-blind placebo controlled study of antioxidant treatment for tardive dyskinesia(TD) conducted by the Department of Veteran Affairs Cooperative Studies Program. One of the principal out come measures of this study is the score derived from the instrumental assessment of upper extremity dyskinesia, Dyskinetic hand movements are quantified by assessing the variability associated with steady-state isometric force generated by the patient. In the present report: we describe the training procedures and results of a multi-center reliability assessment of this procedure. Data from nine study centers comprising 45 individual patients with six trials each (three from left hand and three from right hand) were reanalyzed by an independent investigator and the results were subjected to reliability assessment. For the statistic of interest (average coefficient of variation over trials 2 and 3 for each hand, then take the larger of these two values), we found very high intraclass correlation coefficients for reliability over all patients across sites (ICC =0.995), We also calculated the reliability of the measures across trials within patient for each combination of hand (right, left, dominant), rater group (site, control), and trials set (all three, trials 2 and 3). For a given hand and trial set, the reliability of the site raters was similar to that of the control, This study demonstrates that instrumental measures for the assessment of dyskinesia are reliable and can be implemented in multi-center studies with minimal training.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:41:26