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Titolo:
Mouse hepatitis virus
Autore:
Haring, J; Perlman, S;
Indirizzi:
Univ Iowa, Dept Microbiol, Med Labs 2042, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 , Med Labs 2042, Iowa City, IA 52242 USA
Titolo Testata:
CURRENT OPINION IN MICROBIOLOGY
fascicolo: 4, volume: 4, anno: 2001,
pagine: 462 - 466
SICI:
1369-5274(200108)4:4<462:MHV>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; CD8(+) T-CELLS; INDUCED DEMYELINATING ENCEPHALOMYELITIS; NEUROTROPIC CORONAVIRUS; VIRAL PERSISTENCE; EFFECTOR FUNCTION; JHM VIRUS; INFECTION; PATHOGENESIS; EXPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Haring, J Univ Iowa, Dept Microbiol, Med Labs 2042, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 2042, Iowa City, IA 52242 USA
Citazione:
J. Haring e S. Perlman, "Mouse hepatitis virus", CURR OPIN M, 4(4), 2001, pp. 462-466

Abstract

Inoculation of mice with most neurotropic strains of the coronavirus mousehepatitis virus results in an immune response-mediated demyelinating disease that serves as an excellent animal model for the human disease multiple sclerosis. Recent work has shown that either virus-specific CD4(+) or CD8(+) T cells are able to mediate demyelination and also that the antibody response is crucial for clearing infectious virus. Another exciting advance is the development of recombinant coronaviruses, which, for the first time, will allow genetic manipulation of the entire viral genome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:43:51