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Titolo:
The unexpected contribution of immunosenescence to the leveling off of cancer incidence and mortality in the oldest old
Autore:
Bonafe, M; Valensin, S; Gianni, W; Marigliano, V; Franceschi, C;
Indirizzi:
Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 t Expt Pathol, I-40126 Bologna, Italy Univ Roma La Sapienza, Inst Med Clin 1, Div Geriatr, Rome, Italy Univ RomaLa Sapienza Rome Italy t Med Clin 1, Div Geriatr, Rome, Italy INRCA, Dept Gerontol Res, Ancona, Italy INRCA Ancona ItalyINRCA, Dept Gerontol Res, Ancona, Italy
Titolo Testata:
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
fascicolo: 3, volume: 39, anno: 2001,
pagine: 227 - 233
SICI:
1040-8428(200109)39:3<227:TUCOIT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER NK; CD8(+) T-CELLS; EVOLUTIONARY PERSPECTIVE; CLONAL EXPANSIONS; INNATE IMMUNITY; CENTENARIANS; LYMPHOCYTES; AGE; LONGEVITY; CD4(+);
Keywords:
cancer; immunosenescence; natural killer cells; T lymphocytes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Franceschi, C Univ Bologna, Dept Expt Pathol, Via San Giacomo 12, I-40126 Bologna, Italy Univ Bologna Via San Giacomo 12 Bologna Italy I-40126 Italy
Citazione:
M. Bonafe et al., "The unexpected contribution of immunosenescence to the leveling off of cancer incidence and mortality in the oldest old", CR R ONC H, 39(3), 2001, pp. 227-233

Abstract

In this paper the hypothesis that some features of immuno senescence mightimpact on the levelling off of cancer incidence and mortality in the oldest old will be considered. In fact, the term immuno senescence suggests thata progressive loss of immune system (IS) function occurs with aging. However, the age-related modifications of the IS can be more properly acknowledged as a 'remodeling' characterized by profound structural changes, which modify the functional properties of IS. We suggest that the expansion with age of natural killer cells (NK) and of T cells which progressively acquire phenotypes intermediate between T lymphocytes and NK cells, together with the age-related changes in the production of inflammatory/anti-inflammatory cytokines, such as INF gamma and IL-4, might create an environment unfavorable for neoplastic growth in the oldest old. In this perspective, studies onimmunosenescence likely provide insights on mechanisms responsible for theindividual capacity to escape from the life-threatening consequences of cancer outgrowth. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:59:48