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Titolo:
Metabolites of dietary 1,8-cineole in the male koala (Phascolarctos cinereus)
Autore:
Boyle, R; McLean, S; Foley, W; Davies, NW; Peacock, EJ; Moore, B;
Indirizzi:
Univ Tasmania, Tasmanian Sch Pharm, Hobart, Tas 7001, Australia Univ Tasmania Hobart Tas Australia 7001 harm, Hobart, Tas 7001, Australia Australian Natl Univ, Div Bot & Zool, Canberra, ACT 0200, Australia Australian Natl Univ Canberra ACT Australia 0200 rra, ACT 0200, Australia Univ Tasmania, Cent Sci Lab, Hobart, Tas 7001, Australia Univ Tasmania Hobart Tas Australia 7001 Lab, Hobart, Tas 7001, Australia
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 4, volume: 129, anno: 2001,
pagine: 385 - 395
SICI:
1532-0456(200108)129:4<385:MOD1IT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSSUM URINARY METABOLITES; BRUSHTAIL POSSUM; TRICHOSURUS-VULPECULA; ALPHA-PINENE; BETA-PINENE; RHO-CYMENE; P-CYMENE; BIOTRANSFORMATION; RABBITS; TERPENES;
Keywords:
1,8-cincole; detoxification; Eucalyptus; koala; metabolism; Phascolarctos cinereus; terpene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Boyle, R Univ Tasmania, Tasmanian Sch Pharm, GPO Box 252-26, Hobart, Tas 7001, Australia Univ Tasmania GPO Box 252-26 Hobart Tas Australia 7001 Australia
Citazione:
R. Boyle et al., "Metabolites of dietary 1,8-cineole in the male koala (Phascolarctos cinereus)", COMP BIOC C, 129(4), 2001, pp. 385-395

Abstract

The in vivo metabolic fate of 1,8-cineole was investigated in six male koalas. Koalas were fed ad lib a diet of Eucalyptus cephalocarpa leaf with a 1,8-cineole concentration of 2.53 +/- 0.70% dry mass of leaf, corresponding to a 1,8-cineole intake of 2.4 +/- 1.1 mmol/kg (3.1 +/- 1.3 g). Urine and faeces were collected for 24 h and metabolites identified by GC-MS and LC-MS. Metabolites were quantified before and after hydrolysis with P-glucuronidase to give free and total levels, respectively. Fractional recovery of ingested 1,8-cineole was 1.3 +/- 0.4 and 1.4 +/- 0.4 (mean S.D.) for free and total measurements, respectively. Seven metabolites were identified and quantified: 9- and 7-hydroxycincole, 9- and 7-cineolic acid, 7-hydroxy-9-cineolic acid, 9-hydroxy-7-cineolic acid and 7,9-dicineolic acid. The hydroxycincolic acids dominated the metabolite profile (85%). 7,9-Dicineolic acid, a novel metabolite of 1,8-cineole, accounted for almost 10% of the recovered dose making it the second most abundant metabolite after 7-hydroxy-9-cincolic acid (77%). Together, the less oxidised metabolites, the hydroxycineolesand cineolic acid, accounted for only 5% of the cineole consumed. Significant conjugation only occurred with four minor, less oxidised, alcohol and carboxylic acid metabolites. We have shown that the koala detoxifies and eliminates 1,8-cineole primarily by extensive oxidation without utilising conjugation pathways. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/18 alle ore 07:42:43