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Titolo:
Biochemical and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in immature male and female chickens
Autore:
El-Sabeawy, F; Enan, E; Lasley, B;
Indirizzi:
Univ Calif Davis, Inst Toxicol & Environm Hlth, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 & Environm Hlth, Davis, CA 95616 USA Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37212 USA VanderbiltUniv Nashville TN USA 37212 t Biochem, Nashville, TN 37212 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 4, volume: 129, anno: 2001,
pagine: 317 - 327
SICI:
1532-0456(200108)129:4<317:BATEO2>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE TRANSPORTING ACTIVITY; LIPOPROTEIN-LIPASE ACTIVITY; ADIPOSE-TISSUE; GUINEA-PIG; RECEPTOR-BINDING; CAUSES REDUCTION; GENE-EXPRESSION; TCDD; RATS; LIPOGENESIS;
Keywords:
2,3,7,8-tetrachlorodibenzo-p-dioxin; chickens; adipose tissue; wasting syndrome; hepatomegaly; lipoprotein lipase; glucose transporters; CYP1A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Lasley, B Univ Calif Davis, Inst Toxicol & Environm Hlth, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 m Hlth, Davis, CA 95616 USA
Citazione:
F. El-Sabeawy et al., "Biochemical and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in immature male and female chickens", COMP BIOC C, 129(4), 2001, pp. 317-327

Abstract

It has been reported that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced body wasting in mammals is associated with decreased adipose tissue lipoprotein lipase (LPL) and glucose transporting (GT) activity with differential sensitivity between genders. This study extends those findings to chickens as an avian model. A significant decrease in body weight gain was demonstrated in immature male and female chickens 10 days after treatment with a single intraperitoneal (i.p.) dose of 10 and 100 mug TCDD/kg. Body weight gain decrease was associated with hepatomegaly and induction of hepatic CYP1A enzymes in both genders. The increase in liver/body weight ratio (48%) and the decreased LPL activity (28%) were significant only in females at 10 mug TCDD/kg. However, the increase in liver/body weight ratio (31%) and the decrease in LPL activity (26%) were significantly demonstrated in males at 100 tg TCDD/kg. Levels of GT were significantly decreased in females (46%) and in males (48%) following treatment with 10 mug TCDD/kg and 100 mug TCDD/kg, respectively. Therefore, in chickens, as in mammals, the TCDD-induced body wasting is accompanied with decreased LPL activity and decreased GT activity and the magnitude of these changes is gender dependent. In contrast to mammals, this study suggests that female chickens are equally, if not more responsive to TCDD toxicity than males. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:12:07