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Titolo:
Maturation-dependent neointima formation in fowl aorta
Autore:
Nishimura, H; Xi, Z; Zhang, L; Kempf, H; Wideman, RF; Corvol, P;
Indirizzi:
Univ Tennessee, Ctr Hlth Sci, Dept Physiol, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 , Dept Physiol, Memphis, TN 38163 USA Coll France, Expt Med Lab, INSERM, U36, F-75005 Paris, France Coll FranceParis France F-75005 Lab, INSERM, U36, F-75005 Paris, France Univ Arkansas, Dept Poultry Sci, Poultry Sci Ctr, Fayetteville, AR 72701 USA Univ Arkansas Fayetteville AR USA 72701 i Ctr, Fayetteville, AR 72701 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 1, volume: 130, anno: 2001,
pagine: 39 - 54
SICI:
1095-6433(200108)130:1<39:MNFIFA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAVY-CHAIN ISOFORMS; SMOOTH-MUSCLE CELLS; PULMONARY-ARTERY; BLOOD-PRESSURE; ATHEROSCLEROSIS; HYPERTENSION; ENDOTHELIUM; EXPRESSION; ACETYLCHOLINE; RELAXATION;
Keywords:
blood pressure; neointimal plaque; subendothelial hyperplasia; plasma arginine; plasma cholesterol; age-dependent phenotypes; alpha smooth muscle actin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Nishimura, H Univ Tennessee, Ctr Hlth Sci, Dept Physiol, 894 Union Ave, Memphis, TN 38163 USA Univ Tennessee 894 Union Ave Memphis TN USA 38163 N 38163 USA
Citazione:
H. Nishimura et al., "Maturation-dependent neointima formation in fowl aorta", COMP BIOC A, 130(1), 2001, pp. 39-54

Abstract

Fowl show spontaneous elevation of blood pressure (BP) and neointimal plaque formation in the abdominal aorta at young ages. Maturation/ age-dependent modulation of vascular lesions and a causal relationship between elevatedBP and neointima formation, however, have not been clarified. We thereforeintended to characterize, first, maturation/age-dependent neointimal plaque formation and vascular lesions and, second, their relationship to BP elevation. The BP measured in conscious domestic fowl, Gallus gallus, White Leghorn breed, DeKalb strain, via an indwelling catheter inserted into the ischiadic artery, increased with maturation in males; and at plateau level, BP(mmHg) was significantly (P < 0.01) higher in males (194.0 +/- 4.6, n = 11) than in females (169.3 +/- 3.1, n = 10). Neointimal plaques consisting ofneointimal cells and abundant extracellular matrix appeared initially in the distal segment of the abdominal aorta (lesion-prone area) of chicks as early as 6 weeks old. The area (size) of neointimal plaques right above the ischiadic bifurcation increased with maturation, whereas the plaque area became smaller with some degenerative changes in adult birds. In some birds, diffuse subendothelial hyperplasia and more extensive plaque formation at the branching points of the aorta were observed. The plaque area appears to be larger in birds. particularly in males that have higher BP (r = 0.68). The width of aortic smooth muscle (SM) layers, measured in regions with no plaque, increased with age, whereas the number of cells per unit of area decreased, suggesting that hypertrophy of vascular SM occurs in response to exposure of the vascular wall to high BP. The number of cells was significantly (P < 0.01) higher in the plaque than in underlying aortic SM layers or in layers with no plaque formation. Both neointimal plaques and underlying SM layers are immunohistochemically positive for alpha SM actin, suggesting that neointimal cells are modulated SM cells, whereas the staining with SM myosin heavy chain antibody is low in neointimal plaques. Furthermore. plasma arginine levels dropped in accordance with the time of neointimal plaqueformation, whereas plasma cholesterol levels showed an age-dependent increase. The results suggest that spontaneous development of neointimal plaquesmay be a consequence of exposure to high BP and associated local hemodynamic changes. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:14:04