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Titolo:
Sympathetic and reflex abnormalities in heart failure secondary to ischaemic or idiopathic dilated cardiomyopathy
Autore:
Grassi, G; Seravallet, G; Bertinieri, G; Turri, C; Stella, ML; Scopellit, F; Mancia, G;
Indirizzi:
Univ Milano Bicocca, Med Clin, Osped San Gerardo Tintori, I-20052 Monza, Italy Univ Milano Bicocca Monza Italy I-20052 do Tintori, I-20052 Monza, Italy Ctr Auxol Italiano Piancavallo, I-20149 Milan, Italy Ctr Auxol Italiano Piancavallo Milan Italy I-20149 I-20149 Milan, Italy Osped Policlin, Ctr Fisiol Clin & Ipertens, Ist Ricovero & Cura Carattere Scintif, I-20122 Milan, Italy Osped Policlin Milan Italy I-20122 rattere Scintif, I-20122 Milan, Italy
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 2, volume: 101, anno: 2001,
pagine: 141 - 146
SICI:
0143-5221(200108)101:2<141:SARAIH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA NOREPINEPHRINE; NERVOUS ACTIVITY; VENTRICULAR DYSFUNCTION; BAROREFLEX CONTROL; SENSITIVITY; IMPAIRMENT;
Keywords:
arterial baroreceptors; autonomic nervous system; heart failure; sympathetic activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Mancia, G Univ Milano Bicocca, Med Clin, Milan, Italy Univ Milano BicoccaMilan Italy cocca, Med Clin, Milan, Italy
Citazione:
G. Grassi et al., "Sympathetic and reflex abnormalities in heart failure secondary to ischaemic or idiopathic dilated cardiomyopathy", CLIN SCI, 101(2), 2001, pp. 141-146

Abstract

Congestive heart failure (CHF) is characterized by a sympathetic activation and a baroreflex impairment whose degree is directly related to the clinical severity of the disease. However, whether these abnormalities vary according to the ischaemic or idiopathic dilated nature of the CHF state has not been conclusively documented. In patients with a clinically stable, chronic CHF state in New York Heart Association functional class II and III, dueeither to ischaemic heart disease (IHD; n = 22, age 60.3 +/-2.4 years, means +/-S.E.M.) or to idiopathic dilated cardiomyopathy (IDC; n = 20, age 58.9 +/-2.8 years), and in 30 age-matched controls, we measured arterial bloodpressure (using a Finapres device), heart rate (by electrocardiogram) and postganglionic muscle sympathetic nerve traffic (by microneurography) at rest and during baroreceptor manipulation induced by the vasoactive drug-infusion technique. Blood pressure values were not significantly different in CHF patients and controls. Compared with controls, heart rate was similarly increased and left ventricular ejection fraction (by echocardiography) similarly reduced in CHF patients with IHD or IDC. Muscle sympathetic nerve traffic was significantly greater in CHF patients than in controls, and did not differ between patients with IHD or IDC (67.3 +/-4.2 and 67.8 +/-3.8 bursts/100 heart beats respectively). This was also the case for the degree of baroreflex impairment. These data show that CHF states due to IHD or to IDCare characterized by a similar degree of peripheral sympathetic activationand by a similar impairment of the baroreflex function. Thus the neuroadrenergic and reflex abnormalities characterizing CHF are independent of its aetiology.

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Documento generato il 24/11/20 alle ore 22:49:18