Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
In vivo inhibition of renal 11,beta-hydroxysteroid dehydrogenase in the rat stimulates collecting duct sodium reabsorption
Autore:
Bailey, MA; Unwin, RJ; Shirley, DG;
Indirizzi:
Middlesex Hosp, Inst Urol & Nephrol, Ctr Nephrol, London W1N 8AA, England Middlesex Hosp London England W1N 8AA r Nephrol, London W1N 8AA, England
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 2, volume: 101, anno: 2001,
pagine: 195 - 198
SICI:
0143-5221(200108)101:2<195:IVIOR1>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPARENT MINERALOCORTICOID EXCESS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; ALDOSTERONE; KIDNEY; CARBENOXOLONE; TRANSPORT; RECEPTOR; BINDING;
Keywords:
carbenoxolone; collecting ducts; corticosterone; 11,beta-hydroxysteroid dehydrogenase; sodium reabsorption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Shirley, DG Middlesex Hosp, Inst Urol & Nephrol, Ctr Nephrol, Mortimer St,London W1N 8AA, England Middlesex Hosp Mortimer St London England W1N 8AAAA, England
Citazione:
M.A. Bailey et al., "In vivo inhibition of renal 11,beta-hydroxysteroid dehydrogenase in the rat stimulates collecting duct sodium reabsorption", CLIN SCI, 101(2), 2001, pp. 195-198

Abstract

In order to test the proposal that the aldosterone specificity of mineralocorticoid receptors in the collecting duct depends on inactivation of glucocorticoids by the enzyme 11 beta -hydroxysteroid dehydrogenase (11 beta -HSD), we have assessed the effect of pharmacological inhibition of 11 beta -HSD on collecting duct Na+ reabsorption in vivo. Adrenalectomized rats (n = 14) were infused intravenously with high-dose corticosterone, and late-distal tubules were perfused orthogradely with artificial tubular fluid containing [C-14]inulin and Na-22; urinary recoveries of the radioisotopes were monitored. Half of the rats received intravenous carbenoxolone to inhibit renal 11 beta -HSD activity. The urinary recovery of [C-14]inulin was completein both groups of animals (101 +/- 2% versus 101 +/- 3%), but the recoveryof Na-22 was lower in carbenoxolone-treated rats (34 +/- 5%) than in the corticosterone-alone group (54 +/- 4%, P < 0.01). These data, which provide the first demonstration of enhanced Na+ reabsorption in the distal nephron during inhibition of renal 11 beta -HSD in vivo, strongly support the proposal that 11 beta -HSD normally prevents endogenous glucocorticoid from exerting mineralocorticoid-like effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/07/18 alle ore 00:01:17